Poly(2-ethyl-2-oxazoline) as Alternative for the Stealth Polymer Poly(ethylene glycol): Comparison of in vitro Cytotoxicity and Hemocompatibility
Bauer M, Lautenschlaeger C, Kempe K, Tauhardt L, Schubert US, Fischer D (2012)
Publication Type: Journal article
Publication year: 2012
Journal
Book Volume: 12
Pages Range: 986-998
Journal Issue: 7
Abstract
Limitations of PEG in drug delivery have been reported from clinical trials. PEtOx (0.4-40kDa) as alternative is synthesized by a living, microwave-assisted polymerization, and is directly compared to PEG of similar molar mass regarding cytotoxicity and hemocompatibility. In short-term treatments, both types of polymers are well tolerated even at high concentrations. Moderate concentration and molar mass dependent cytotoxic effects occurred only after long-term incubation at concentrations higher than therapeutic doses. PEtOx possesses not only an easy route of synthesis and beneficial physicochemical characteristics such as low viscosity and high stability, which are advantageous over PEG, but additionally in vitro toxicology comparable to PEG. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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APA:
Bauer, M., Lautenschlaeger, C., Kempe, K., Tauhardt, L., Schubert, U.S., & Fischer, D. (2012). Poly(2-ethyl-2-oxazoline) as Alternative for the Stealth Polymer Poly(ethylene glycol): Comparison of in vitro Cytotoxicity and Hemocompatibility. Macromolecular Bioscience, 12(7), 986-998. https://doi.org/10.1002/mabi.201200017
MLA:
Bauer, Marius, et al. "Poly(2-ethyl-2-oxazoline) as Alternative for the Stealth Polymer Poly(ethylene glycol): Comparison of in vitro Cytotoxicity and Hemocompatibility." Macromolecular Bioscience 12.7 (2012): 986-998.
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