Role of type IV secretion in Helicobacter pylori pathogenesis

Backert S, Selbach M (2008)

Publication Type: Journal article, Review article

Publication year: 2008

Journal

Cellular Microbiology Wiley

Book Volume: 10

Pages Range: 1573-1581

Journal Issue: 8

DOI: 10.1111/j.1462-5822.2008.01156.x

Abstract

Helicobacter pylori is a highly successful human-specific gastric pathogen that colonizes more than half the world's population. Infection with this bacterium can induce gastric pathologies ranging from chronic gastritis to peptic ulcers and even cancer. Virulent H. pylori isolates harbour the cag (cytotoxin-associated genes) pathogenicity island, a 40kb stretch of DNA that encodes components of a type IV secretion system (T4SS). This T4SS forms a pilus for the injection of virulence factors into host target cells such as the CagA oncoprotein. This is accomplished by a specialized adhesin of the pilus surface, the CagL protein, which binds to and activates host cell integrins for subsequent delivery of CagA across the host cell membrane. Injected CagA becomes tyrosine-phosphorylated by Src and Abl family kinases and mimics a host cell protein in binding and activation of multiple signalling factors. Here we review the recent advances in the characterization of phosphorylation-dependent and phosphorylation-independent signalling activities of CagA and the T4SS which include the induction of membrane dynamics, actin cytoskeletal rearrangements and the disruption of cell-to-cell junctions as well as proliferative, pro-inflammatory and anti-apoptotic nuclear responses. The contribution of these signalling cascades to H. pylori pathogenesis is discussed. © 2008 The Authors Journal compilation © 2008 Blackwell Publishing Ltd.

Authors with CRIS profile

Steffen Backert

Involved external institutions

Max-Delbrück-Centrum für Molekulare Medizin / Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch DE Germany (DE) Otto-von-Guericke-Universität Magdeburg DE Germany (DE)

How to cite

APA:

Backert, S., & Selbach, M. (2008). Role of type IV secretion in Helicobacter pylori pathogenesis. Cellular Microbiology, 10(8), 1573-1581. https://doi.org/10.1111/j.1462-5822.2008.01156.x

MLA:

Backert, Steffen, and Matthias Selbach. "Role of type IV secretion in Helicobacter pylori pathogenesis." Cellular Microbiology 10.8 (2008): 1573-1581.

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