Serine phosphorylation of cortactin controls focal adhesion kinase activity and cell scattering induced by Helicobacter pylori

Tegtmeyer N, Wittelsberger R, Hartig R, Wessler S, Martinez-Quiles N, Backert S (2011)

Publication Type: Journal article

Publication year: 2011

Journal

Cell Host & Microbe Elsevier (Cell Press)

Book Volume: 9

Pages Range: 520-531

Journal Issue: 6

DOI: 10.1016/j.chom.2011.05.007

Abstract

Cell migration and invasion require the coordinated regulation of cytoskeletal architectural changes by signaling factors, including the actin-binding protein cortactin. Bacterial and viral pathogens subvert these signaling factors to promote their uptake, spread and dissemination. We show that the gastric pathogen Helicobacter pylori (Hp) targets cortactin by two independent processes leading to its tyrosine dephosphorylation and serine phosphorylation to regulate cell scattering and elongation. The phosphorylation status of cortactin dictates its subcellular localization and signaling partners. Upon infection, cortactin was found to interact with and stimulate the kinase activity of focal adhesion kinase (FAK). This interaction required the SH3 domain and phosphorylation of cortactin at serine 405 and a proline-rich sequence in FAK. Using Hp as a model, this study unravels a previously unrecognized FAK activation pathway. We propose that Hp targets cortactin to protect the gastric epithelium from excessive cell lifting and ensure sustained infection in the stomach. © 2011 Elsevier Inc.

Authors with CRIS profile

Nicole Tegtmeyer-Backert
Steffen Backert

Involved external institutions

Universität Salzburg (Paris Lodron Universität Salzburg) AT Austria (AT) Otto-von-Guericke-Universität Magdeburg DE Germany (DE) Universidad Complutense de Madrid (UCM) ES Spain (ES)

How to cite

APA:

Tegtmeyer, N., Wittelsberger, R., Hartig, R., Wessler, S., Martinez-Quiles, N., & Backert, S. (2011). Serine phosphorylation of cortactin controls focal adhesion kinase activity and cell scattering induced by Helicobacter pylori. Cell Host & Microbe, 9(6), 520-531. https://doi.org/10.1016/j.chom.2011.05.007

MLA:

Tegtmeyer, Nicole, et al. "Serine phosphorylation of cortactin controls focal adhesion kinase activity and cell scattering induced by Helicobacter pylori." Cell Host & Microbe 9.6 (2011): 520-531.

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