Gahbauer S, Böckmann R (2020)
Publication Status: Published
Publication Type: Journal article
Publication year: 2020
Book Volume: 124
Pages Range: 2823-2834
Journal Issue: 14
Dimerization of G protein-coupled receptors (GPCRs) is considered to take part in regulating the highly dynamic nature of receptor function. Intensive research unraveled a large variety of different dimer configurations with potentially distinct activity profiles. Studies are complicated by the critical role of the membrane environment for receptor dimerization, and experimental deficiencies in modulating the same. Here we chose a molecular dynamics strategy to characterize the potential of the large chemical lipid repertoire to steer dimerization fingerprints of the neurotensin 1 receptor. Unfavorable hydrophobic mismatch results in excessive dimerization whereas particular lipid features, e.g., anionic headgroups, induce specific dimer interfaces via direct protein-lipid interactions. Polyunsaturated fatty acids attenuate compact dimer formation by facilitated adhesion to the protein transmembrane surface, and receptor lipidation-induced conformational changes confer modulated protein-lipid and protein-protein interactions. Our results highlight the striking role of the membrane environment on GPCR dimerization with potential functional consequences.
APA:
Gahbauer, S., & Böckmann, R. (2020). Comprehensive Characterization of Lipid-Guided G Protein-Coupled Receptor Dimerization. Journal of Physical Chemistry B, 124(14), 2823-2834. https://doi.org/10.1021/acs.jpcb.0c00062
MLA:
Gahbauer, Stefan, and Rainer Böckmann. "Comprehensive Characterization of Lipid-Guided G Protein-Coupled Receptor Dimerization." Journal of Physical Chemistry B 124.14 (2020): 2823-2834.
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