On PTV definition for glioblastoma based on fiber tracking of diffusion tensor imaging data

Witulla B, Goerig N, Putz F, Frey B, Engelhorn T, Dörfler A, Uder M, Fietkau R, Bert C, Laun FB (2020)

Publication Type: Journal article

Publication year: 2020

Journal

PLoS ONE Public Library of Science

Book Volume: 15

Pages Range: e0227146-

Journal Issue: 1

DOI: 10.1371/journal.pone.0227146

Abstract

Radiotherapy (RT) is commonly applied for the treatment of glioblastoma multiforme (GBM). Following the planning target volume (PTV) definition procedure standardized in guidelines, a 20% risk of missing non-local recurrences is present. Purpose of this study was to evaluate whether diffusion tensor imaging (DTI)-based fiber tracking may be beneficial for PTV definition taking into account the prediction of distant recurrences. 56 GBM patients were examined with magnetic resonance imaging (MRI) including DTI performed before RT after resection of the primary tumor. Follow-up MRIs were acquired in three month intervals. For the seven patients with a distant recurrence, fiber tracking was performed with three algorithms and it was evaluated whether connections existed from the primary tumor region to the distant recurrence. It depended strongly on the used tracking algorithm and the used tracking parameters whether a connection was observed. Most of the connections were weak and thus not usable for PTV definition. Only in one of the seven patients with a recurring tumor, a clear connection was present. It seems unlikely that DTI-based fiber tracking can be beneficial for predicting distant recurrences in the planning of PTVs for glioblastoma multiforme.

Authors with CRIS profile

Barbara Witulla Professur für Med. Strahlenphysik Nicole Goerig Department of Radiation Oncology Florian Putz Department of Radiation Oncology Benjamin Frey Department of Radiation Oncology Tobias Martin Engelhorn Department of Neuroradiology Arnd Dörfler Department of Neuroradiology Michael Uder Lehrstuhl für Diagnostische Radiologie Rainer Fietkau Lehrstuhl für Strahlentherapie Christoph Bert Professur für Med. Strahlenphysik Frederik Bernd Laun Professur für quantitative MR-Bildgebung (Heisenberg-Professur)

How to cite

APA:

Witulla, B., Goerig, N., Putz, F., Frey, B., Engelhorn, T., Dörfler, A.,... Laun, F.B. (2020). On PTV definition for glioblastoma based on fiber tracking of diffusion tensor imaging data. PLoS ONE, 15(1), e0227146-. https://doi.org/10.1371/journal.pone.0227146

MLA:

Witulla, Barbara, et al. "On PTV definition for glioblastoma based on fiber tracking of diffusion tensor imaging data." PLoS ONE 15.1 (2020): e0227146-.

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