Feedback regulation of mitochondrial homeostasis via Wnt/β-catenin signaling

Bernkopf D, Behrens J (2018)

Publication Type: Journal article

Publication year: 2018

Journal

Molecular & Cellular Oncology Taylor & Francis

Book Volume: 5

Journal Issue: 3

DOI: 10.1080/23723556.2018.1458015

Abstract

Cellular abundance of mitochondria is dynamically regulated. We could recently show that dysfunctional mitochondria release the phosphatase PGAM family member 5 (PGAM5) into the cytosol, where it interacts with the Wnt signaling-component AXIN1 and dephosphorylates AXIN1-bound β-catenin (CTNNB1) thereby activating Wnt/β-catenin signaling. Because Wnt/β-catenin signaling induces mitochondrial biogenesis dysfunctional mitochondria trigger their own replacement by releasing PGAM5.

Authors with CRIS profile

Dominic Bernkopf Lehrstuhl für Experimentelle Medizin II (Molekulare Tumorforschung) Jürgen Behrens Lehrstuhl für Experimentelle Medizin II (Molekulare Tumorforschung)

Additional Organisation(s)

Interdisziplinäres Zentrum für Klinische Forschung

How to cite

APA:

Bernkopf, D., & Behrens, J. (2018). Feedback regulation of mitochondrial homeostasis via Wnt/β-catenin signaling. Molecular & Cellular Oncology, 5(3). https://doi.org/10.1080/23723556.2018.1458015

MLA:

Bernkopf, Dominic, and Jürgen Behrens. "Feedback regulation of mitochondrial homeostasis via Wnt/β-catenin signaling." Molecular & Cellular Oncology 5.3 (2018).

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