In vivo potassium MRI of the human heart

Wenz D, Nagel AM, Lott J, Kuehne A, Niesporek SC, Niendorf T (2019)

Publication Type: Journal article

Publication year: 2019

Journal

Magnetic Resonance in Medicine Wiley

DOI: 10.1002/mrm.27951

Abstract

Purpose Potassium ions (K+) play a critical role in cardiac electrophysiology, and changes in their concentration reflect pathophysiological processes related to cardiovascular diseases. Here, we investigated the feasibility of in vivo K-39 MRI of the human heart. To achieve this, we developed, evaluated, and applied a K-39/H-1 RF coil, which is tailored for K-39 MRI of human heart at 7.0T. Methods The performance of the K-39/H-1 RF coil was evaluated by electromagnetic field and specific absorption ratio simulations using 2 (male/female) human voxel models. The RF coil was evaluated at the bench and applied in an in vivo proof-of-principle study involving 7 healthy volunteers. The experiments were performed using a 7.0T whole-body MR system in conjunction with a 3D density-adapted projection reconstruction imaging technique. Results For in vivo K-39 MRI of the human heart, a nominal spatial resolution of 14.5 x 14.5 x 14.5 mm(3) within a total scan time of 30 min was achieved. The average SNR within the heart was 9.6 +/- 2.4. Conclusion This work validates the design of a K-39/H-1 RF coil for cardiac MR at 7.0T and demonstrates for the first time in vivo the feasibility of K-39 MRI of the human heart.

Authors with CRIS profile

Armin Michael Nagel Professur für metabolische und funktionelle MR-Bildgebung

Involved external institutions

Max-Delbrück-Centrum für Molekulare Medizin / Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch DE Germany (DE) Deutsches Krebsforschungszentrum (DKFZ) DE Germany (DE) MRI.TOOLS GmbH DE Germany (DE)

How to cite

APA:

Wenz, D., Nagel, A.M., Lott, J., Kuehne, A., Niesporek, S.C., & Niendorf, T. (2019). In vivo potassium MRI of the human heart. Magnetic Resonance in Medicine. https://dx.doi.org/10.1002/mrm.27951

MLA:

Wenz, Daniel, et al. "In vivo potassium MRI of the human heart." Magnetic Resonance in Medicine (2019).

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