Culemann S, Grüneboom A, Krönke G (2019)
Publication Type: Book chapter / Article in edited volumes
Publication year: 2019
Publisher: Academic Press Inc.
Edited Volumes: Advances in Immunology
DOI: 10.1016/bs.ai.2019.08.006
Mononuclear phagocytes, including monocytes and macrophages, are a central component of the host's innate immune system designated to protect against invading pathogens. However, these cells do not only interact with various parts of the innate and adaptive immune system, but also fulfill indispensable duties during the control of tissue homeostasis and organ function. Moreover, macrophages are crucially involved in tissue remodeling and repair in response to damage. Simultaneously, mononuclear phagocytes might also contribute to the pathogenesis of various inflammatory and autoimmune diseases. In particular, their potential role in inflammatory joint diseases such as rheumatoid arthritis (RA) has drawn increasing attention and substantially shaped our general understanding of the role of monocytes and macrophages during health and disease. This review summarizes our current knowledge about the origin and function of mononuclear phagocytes within the joint and addresses their involvement in joint inflammation.
APA:
Culemann, S., Grüneboom, A., & Krönke, G. (2019). Origin and function of synovial macrophage subsets during inflammatory joint disease. In Advances in Immunology. Academic Press Inc..
MLA:
Culemann, Stephan, Anika Grüneboom, and Gerhard Krönke. "Origin and function of synovial macrophage subsets during inflammatory joint disease." Advances in Immunology. Academic Press Inc., 2019.
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