First-year predictors of health-related quality of life changes in short-statured children treated with human growth hormone
Quitmann J, Bloemeke J, Dörr HG, Bullinger M, Witt S, Silva N (2019)
Publication Type: Journal article
Publication year: 2019
Journal
Book Volume: 42
Pages Range: 1067-1076
Journal Issue: 9
DOI: 10.1007/s40618-019-01027-4
Abstract
Purpose: Little attention has been directed towards examining the impact of predictors on change in health-related quality of life (HRQOL) within the course of growth hormone (GH) treatment in pediatric short stature. We aimed to assess changes in HRQOL and its sociodemographic, clinical and psychosocial predictors in children and adolescents diagnosed with growth hormone deficiency (GHD), and born short for gestational age (SGA) before and 12-month after start of GH treatment from the parents’ perspective. Results were compared with an untreated group with idiopathic short stature (ISS). In this prospective multicenter study, 152 parents of children/adolescents (aged 4–18 years) provided data on their children’s HRQOL at baseline and at 12-month follow-up. Method: Repeated-measures multivariate analyses of covariance were performed to examine parent-reported HRQOL changes from baseline to 1-year after treatment and hierarchical linear regressions to identify the predictors of HRQOL changes. Results: Results showed that parents of children that were treated with GH report an increase in their children’s HRQOL after 1 year. Changes in HRQOL were mostly explained by psychosocial predictors followed by sociodemographic and clinical variables. Specifically, the diagnosis SGA significantly predicted a greater increase in parent-reported HRQOL. Furthermore, a lower caregiving burden significantly predicted a decrease in parent-reported HRQOL. Conclusion: In conclusion, a substantial percentage of explained variance in HRQOL relates to psychosocial and sociodemographic predictors. However, there appears to be other important factors that are predictors of HRQOL, which need to be determined in large, population-based samples.
Authors with CRIS profile
Helmuth-Günther Dörr
Professur für Kinderheilkunde mit dem Schwerpunkt Kinder-Endokrinologie und Diabetologie (Stiftungsprofessur)
Involved external institutions
Germany (DE)How to cite
APA:
Quitmann, J., Bloemeke, J., Dörr, H.-G., Bullinger, M., Witt, S., & Silva, N. (2019). First-year predictors of health-related quality of life changes in short-statured children treated with human growth hormone. Journal of Endocrinological Investigation, 42(9), 1067-1076. https://dx.doi.org/10.1007/s40618-019-01027-4
MLA:
Quitmann, J., et al. "First-year predictors of health-related quality of life changes in short-statured children treated with human growth hormone." Journal of Endocrinological Investigation 42.9 (2019): 1067-1076.
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