Spatial Distribution of Choriocapillaris Impairment in Eyes with Choroidal Neovascularization Secondary to Age-Related Macular Degeneration

Moult EM, Alibhai AY, Rebhun CB, Lee B, Ploner S, Schottenhamml J, Husvogt L, Baumal CR, Witkin AJ, Maier A, Duker JS, Rosenfeld P, Waheed NK, Fujimoto JG (2019)

Publication Type: Journal article, Original article

Publication year: 2019

Journal

URI: https://journals.lww.com/retinajournal/Abstract/publishahead/SPATIAL_DISTRIBUTION_OF_CHORIOCAPILLARIS.96058.aspx

DOI: 10.1097/IAE.0000000000002556

Abstract

Purpose: To develop an optical coherence tomography angiography (OCTA)-based framework for quantitatively analyzing the spatial distribution of choriocapillaris (CC) impairment around choroidal neovascularization (CNV) secondary to age-related macular degeneration.

Methods: In a retrospective, cross-sectional study, 400-kHz swept-source OCTA images from 7 eyes of 6 patients with CNV secondary to age-related macular degeneration were quantitatively analyzed using custom software. A lesion-centered zonal OCTA analysis technique—which portioned the field-of-view into zones relative to CNV boundaries—was developed to quantify the spatial dependence of CC flow deficits.

Results: Quantitative, lesion-centered zonal analysis of CC OCTA images revealed highest flow-deficit percentages near CNV boundaries, decreasing in zones farther from the boundaries. Optical coherence tomography angiography using shorter (1.5 ms) interscan times revealed more severe flow deficits than OCTA using longer (3.0 ms) interscan times; however, spatial trends were similar for both interscan times. A detailed description of the OCTA processing steps and parameters was provided so as to elucidate their influence on quantitative measurements.

Conclusion: Impairment of the CC, assessed by flow-deficit percentages, was most prominent closest to CNV boundaries. The lesion-centered zonal analysis technique enabled quantitative CC measurements relative to focal lesions. Understanding how processing steps, imaging/processing parameters, and artifacts can affect quantitative CC measurements is important for longitudinal, OCTA-based studies of disease progression, and treatment response.

Authors with CRIS profile

Related research project(s)

Involved external institutions

Massachusetts Institute of Technology (MIT) United States (USA) (US) University of Miami United States (USA) (US) Tufts Medical Center United States (USA) (US) Tufts University United States (USA) (US)

How to cite

APA:

Moult, E.M., Alibhai, A.Y., Rebhun, C.B., Lee, B., Ploner, S., Schottenhamml, J.,... Fujimoto, J.G. (2019). Spatial Distribution of Choriocapillaris Impairment in Eyes with Choroidal Neovascularization Secondary to Age-Related Macular Degeneration. Retina-The Journal of Retinal and Vitreous Diseases. https://dx.doi.org/10.1097/IAE.0000000000002556

MLA:

Moult, Eric M., et al. "Spatial Distribution of Choriocapillaris Impairment in Eyes with Choroidal Neovascularization Secondary to Age-Related Macular Degeneration." Retina-The Journal of Retinal and Vitreous Diseases (2019).

BibTeX: Download