Straub S, Freitag MT, Kölsche C, von Deimling A, Denoix M, Bendszus M, Schlemmer HP, Ladd ME, Schneider TM, Laun FB (2019)
Publication Type: Journal article
Publication year: 2019
DOI: 10.1007/s00062-019-00816-x
Purpose: To quantify the influence of melanin content on magnetic susceptibility of cerebral melanoma metastases. Methods: Patients with non-hemorrhagic metastases were included based on the absence of susceptibility blooming artifacts. Susceptibility maps were calculated from 3D gradient echo data, using Laplacian-based phase unwrapping, sophisticated harmonic artefact reduction for phase data (V-SHARP) with varying spherical kernel sizes for background field removal and the iLSQR algorithm for the inversion of phase data. Susceptibility maps were referenced to cerebrospinal fluid. Non-hemorrhagic metastases were identified on contrast-enhanced T1-weighted images and susceptibility weighted images. Metastases masks were drawn on T1-weighted post-contrast images and used to compute mean susceptibility values of each metastasis. Results: A total of 33 non-hemorrhagic melanoma brain metastases in 20 patients were quantitatively evaluated. Metastases without and with hyperintense signal on T1-weighted images, which corresponds to the melanin content, showed median susceptibility values of −0.028 ppm and −0.020 ppm, respectively. The susceptibility differences between metastases without and with T1-weighted hyperintense signal was not statistically significant (p ≥ 0.05). Conclusion: Non-hemorrhagic cerebral melanoma metastases showed weak diamagnetic susceptibility values and susceptibility did not significantly correlate to T1-weighted signals. Therefore, melanin does not seem to be a major contributor to susceptibility in cerebral melanoma metastases.
APA:
Straub, S., Freitag, M.T., Kölsche, C., von Deimling, A., Denoix, M., Bendszus, M.,... Laun, F.B. (2019). Assessment of Melanin Content and its Influence on Susceptibility Contrast in Melanoma Metastases. Clinical Neuroradiology. https://dx.doi.org/10.1007/s00062-019-00816-x
MLA:
Straub, Sina, et al. "Assessment of Melanin Content and its Influence on Susceptibility Contrast in Melanoma Metastases." Clinical Neuroradiology (2019).
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