Potential of Exosomes for the Treatment of Stroke
Hong SB, Yang H, Manaenko A, Lu J, Mei Q, Hu Q (2019)
Publication Type: Journal article, Review article
Publication year: 2019
Journal
Book Volume: 28
Pages Range: 662-670
Journal Issue: 6
Abstract
Stroke is the result of blockage or rupture of blood vessels in the brain and is the leading cause of death and disability in the world. Currently only a very limited number of therapeutic approaches are available for treatment of stroke patients, and the vast majority of neuroprotective agents that tested positively in pre-clinical studies failed in clinical trials. In recent years, the clinical value of the use of exosomes for stroke treatment has received widespread attention due their unique characteristics such as low immunogenicity, low toxicity and biodegradability, ability to cross the blood–brain barrier (BBB), and their important role in communication between cells. More and more evidence suggests that the secretion of exosomes is the mechanism underlying the protection induced by mesenchymal stromal cells (MSCs) after stroke. Exosomes are thought to support brain restoration and induce repairing effects, including neurovascular remodeling, and anti-apoptosis and anti-inflammatory effects. Recent reports have focused on the clinical application of exosomes as a potential drug delivery approach. This review focuses on the ability of exosomes to interrupt the stroke-induced pathologic processes of stroke, and on publications describing how to achieve more effective treatment of stroke with exosomes.
Involved external institutions
China (CN)How to cite
APA:
Hong, S.B., Yang, H., Manaenko, A., Lu, J., Mei, Q., & Hu, Q. (2019). Potential of Exosomes for the Treatment of Stroke. Cell Transplantation, 28(6), 662-670. https://dx.doi.org/10.1177/0963689718816990
MLA:
Hong, Shi Bin, et al. "Potential of Exosomes for the Treatment of Stroke." Cell Transplantation 28.6 (2019): 662-670.
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