Duong MT, Holz D, Alkassar M, Dittrich S, Leyendecker S (2019)
Publication Language: English
Publication Type: Journal article, Review article
Publication year: 2019
Book Volume: 10
Pages Range: 10-41
URI: https://www.frontiersin.org/articles/10.3389/fphys.2019.01041/abstract
Open Access Link: https://doi.org/10.3389/fphys.2019.01041
In this paper, we are investigating the interaction between different passive material models
and the mechano-electrical feedback (MEF) in cardiac modelling. Various types of
passive mechanical laws (nearly incompressible/compressible, polynomial/exponential-type,
transversally isotropic/orthotropic material models) are integrated in a fully coupled electromechanical
model in order to study their specific influence on the overall MEF behaviour.
Our computational model is based on a three-dimensional (3D) geometry of a
healthy rat left ventricle reconstructed from magnetic resonance imaging (MRI). The electromechanically
coupled problem is solved using a fully implicit finite element-based approach.
The effects of different passive material models on the MEF are studied with the
help of numerical examples. It turns out that there is a significant difference between the
behaviour of the MEF for compressible and incompressible material models. Numerical results
for the incompressible models exhibit that a change in the electrophysiology can be
observed such that the transmembrane potential (TP) is unable to reach the resting state in
the repolarisation phase and this leads to non-zero relaxation deformations. The most significant
and strongest effects of the MEF on the rat cardiac muscle response are observed
for the exponential passive material law.
APA:
Duong, M.T., Holz, D., Alkassar, M., Dittrich, S., & Leyendecker, S. (2019). Interaction of the mechano-electrical feedback with passive mechanical models on a 3D rat left ventricle: a computational study. Frontiers in Physiology, 10, 10-41. https://dx.doi.org/10.3389/fphys.2019.01041
MLA:
Duong, Minh Tuan, et al. "Interaction of the mechano-electrical feedback with passive mechanical models on a 3D rat left ventricle: a computational study." Frontiers in Physiology 10 (2019): 10-41.
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