BMP6-induced modulation of the tumor micro-milieu

Stieglitz D, Lamm S, Braig S, Feuerer L, Kuphal S, Dietrich P, Arndt S, Echtenacher B, Hellerbrand C, Karrer S, Boßerhoff AK (2019)

Publication Type: Journal article

Publication year: 2019

Journal

Book Volume: 38

Pages Range: 609-621

Journal Issue: 5

DOI: 10.1038/s41388-018-0475-x

Abstract

Melanoma is the deadliest form of skin cancer with rising incidence, creating a significant health problem. We discovered increased expression of bone morphogenetic protein 6 (BMP6) in melanoma cells and tissues, and observed that BMP6 deficiency caused significantly delayed tumor onset and decelerated tumor progression in a melanoma mouse model. Moreover, we determined that BMP6 inhibits dermal mast cell recruitment and found that mast cell-derived mediators significantly reduced melanoma growth in vitro. In line with this, mast cell deficiency accelerated tumor onset and progression in a melanoma mouse model. Analysis of human melanoma tissues revealed a strong negative correlation between melanoma proliferation and mast cell infiltration. This study elucidates a novel role of BMP6-induced modulation of the tumor microenvironment.

Authors with CRIS profile

Additional Organisation(s)

Involved external institutions

Universitätsklinikum Regensburg Germany (DE) Regensburg Center for Interventional Immunology Germany (DE) Ludwig-Maximilians-Universität (LMU) Germany (DE)

How to cite

APA:

Stieglitz, D., Lamm, S., Braig, S., Feuerer, L., Kuphal, S., Dietrich, P.,... Boßerhoff, A.K. (2019). BMP6-induced modulation of the tumor micro-milieu. Oncogene, 38(5), 609-621. https://doi.org/10.1038/s41388-018-0475-x

MLA:

Stieglitz, David, et al. "BMP6-induced modulation of the tumor micro-milieu." Oncogene 38.5 (2019): 609-621.

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