Multisensory integration processing during olfactory-visual stimulation-An fMRI graph theoretical network analysis
Ripp I, Zur Nieden AN, Blankenagel S, Franzmeier N, Lundstrom JN, Freiherr J (2018)
Publication Status: Published
Publication Type: Journal article
Publication year: 2018
Journal
Publisher: WILEY
Book Volume: 39
Pages Range: 3713-3727
Journal Issue: 9
DOI: 10.1002/hbm.24206
Abstract
In this study, we aimed to understand how whole-brain neural networks compute sensory information integration based on the olfactory and visual system. Task-related functional magnetic resonance imaging (fMRI) data was obtained during unimodal and bimodal sensory stimulation. Based on the identification of multisensory integration processing (MIP) specific hub-like network nodes analyzed with network-based statistics using region-of-interest based connectivity matrices, we conclude the following brain areas to be important for processing the presented bimodal sensory information: right precuneus connected contralaterally to the supramarginal gyrus for memory-related imagery and phonology retrieval, and the left middle occipital gyrus connected ipsilaterally to the inferior frontal gyrus via the inferior fronto-occipital fasciculus including functional aspects of working memory. Applied graph theory for quantification of the resulting complex network topologies indicates a significantly increased global efficiency and clustering coefficient in networks including aspects of MIP reflecting a simultaneous better integration and segregation. Graph theoretical analysis of positive and negative network correlations allowing for inferences about excitatory and inhibitory network architectures revealednot significant, but very consistentthat MIP-specific neural networks are dominated by inhibitory relationships between brain regions involved in stimulus processing.
Authors with CRIS profile
Involved external institutions
Ludwig-Maximilians-Universität (LMU)
Germany (DE)
Monell Chemical Senses Center
United States (USA) (US)
Fraunhofer-Institut für Verfahrenstechnik und Verpackung (IVV)
Germany (DE)
Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen
Germany (DE)
Germany (DE)
Monell Chemical Senses Center
United States (USA) (US)
Fraunhofer-Institut für Verfahrenstechnik und Verpackung (IVV)
Germany (DE)
Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen
Germany (DE)
How to cite
APA:
Ripp, I., Zur Nieden, A.-N., Blankenagel, S., Franzmeier, N., Lundstrom, J.N., & Freiherr, J. (2018). Multisensory integration processing during olfactory-visual stimulation-An fMRI graph theoretical network analysis. Human Brain Mapping, 39(9), 3713-3727. https://dx.doi.org/10.1002/hbm.24206
MLA:
Ripp, Isabelle, et al. "Multisensory integration processing during olfactory-visual stimulation-An fMRI graph theoretical network analysis." Human Brain Mapping 39.9 (2018): 3713-3727.
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