Challenging the prognostic impact of the new WHO and TNM classifications with special emphasis on HPV status in penile carcinoma

Hölters S, Khalmurzaev O, Pryalukhin A, Loertzer P, Janssen M, Heinzelbecker J, Ueberdiek S, Pfuhl T, Smola S, Agaimy A, Geppert CI, Loertzer H, Krah X, Wunderlich H, Wagenpfeil S, Bohle RM, Stöckle M, Matveev V, Hartmann A, Junker K (2019)

Publication Type: Journal article

Publication year: 2019

Journal

Virchows Archiv Springer Verlag (Germany)

Book Volume: 475

Pages Range: 211-221

Journal Issue: 2

DOI: 10.1007/s00428-019-02566-0

Abstract

The evidence concerning prognostic parameters for clinical decision-making in penile cancer is either weak or missing. We therefore analysed the prognostic value of the revised TNM and WHO classification systems on relapse and survival with special emphasis on HPV status. We collected clinical data and tissue samples of 121 patients from centres in Germany and Russia. HPV genotyping and p16INK4a immunostaining were performed. The histological subtype and TNM were reclassified by two experienced uropathologists. Survival analyses were performed by Kaplan-Meier estimator and log-rank test. Uni- and multivariable analyses were performed by Cox proportional hazard model and Fisher’s exact test for contingency analysis. HPV status was not found to be an independent prognostic factor. Histological subtypes differ in prognosis with the best outcome found in warty and the worst in basaloid carcinomas. Patients with pT1b defined by poor differentiation or lymphovascular invasion (LVI) had the shortest metastasis-free survival compared with pT1a (log-rank, p = 0.02). Lymph node metastasis and LVI were significantly associated with poor metastasis-free, cancer-specific and overall survival and could be identified as the only independent prognostic parameters. Prognostic value of TNM could not be improved using the 8th versus the 7th edition. In contrast to HPV status, histological subtypes are of prognostic value and should be an essential part of pathologic reports. The impact of the HPV status needs to be analysed in a subtype-specific manner. Parameters describing lymphatic dissemination have the highest impact on prognosis. Inclusion of tumour grade and LVI into a single T-category (pT1b) seems questionable.

Authors with CRIS profile

Abbas Agaimy Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie Carol-Immanuel Geppert Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie Arndt Hartmann Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie

Involved external institutions

Universitätsklinikum des Saarlandes (UKS) DE Germany (DE) HELIOS Kliniken DE Germany (DE) Westpfalz-Klinikum DE Germany (DE) N.N. Blokhin Russian Cancer Research Center / Российский онкологический научный центр им. Н. Н. Блохина RU Russian Federation (RU)

How to cite

APA:

Hölters, S., Khalmurzaev, O., Pryalukhin, A., Loertzer, P., Janssen, M., Heinzelbecker, J.,... Junker, K. (2019). Challenging the prognostic impact of the new WHO and TNM classifications with special emphasis on HPV status in penile carcinoma. Virchows Archiv, 475(2), 211-221. https://doi.org/10.1007/s00428-019-02566-0

MLA:

Hölters, Sebastian, et al. "Challenging the prognostic impact of the new WHO and TNM classifications with special emphasis on HPV status in penile carcinoma." Virchows Archiv 475.2 (2019): 211-221.

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