Choroid plexus-derived miR-204 regulates the number of quiescent neural stem cells in the adult brain

Journal article


Publication Details

Author(s): Lepko T, Pusch M, Mueller T, Schulte D, Ehses J, Kiebler M, Hasler J, Huttner H, Vandenbroucke RE, Vandendriessche C, Modic M, Martin-Villalba A, Zhao S, Llorens-Bobadilla E, Schneider A, Fischer A, Breunig CT, Stricker SH, Goetz M, Ninkovic J
Journal: EMBO Journal
Publication year: 2019
ISSN: 0261-4189
eISSN: 1460-2075


Abstract

Regulation of adult neural stem cell (NSC) number is critical for lifelong neurogenesis. Here, we identified a post-transcriptional control mechanism, centered around the microRNA 204 (miR-204), to control the maintenance of quiescent (q)NSCs. miR-204 regulates a spectrum of transcripts involved in cell cycle regulation, neuronal migration, and differentiation in qNSCs. Importantly, inhibition of miR-204 function reduced the number of qNSCs in the subependymal zone (SEZ) by inducing pre-mature activation and differentiation of NSCs without changing their neurogenic potential. Strikingly, we identified the choroid plexus of the mouse lateral ventricle as the major source of miR-204 that is released into the cerebrospinal fluid to control number of NSCs within the SEZ. Taken together, our results describe a novel mechanism to maintain adult somatic stem cells by a niche-specific miRNA repressing activation and differentiation of stem cells.


FAU Authors / FAU Editors

Huttner, Hagen Prof. Dr.
Medizinische Fakultät


Additional Organisation
Neurologische Klinik


External institutions with authors

Deutsches Krebsforschungszentrum (DKFZ)
Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE)
Flanders Institute for Biotechnology / Vlaams Instituut voor Biotechnologie (VIB)
Goethe-Universität Frankfurt am Main
Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (HMGU)
Ludwig-Maximilians-Universität (LMU)
The Francis Crick Institute


How to cite

APA:
Lepko, T., Pusch, M., Mueller, T., Schulte, D., Ehses, J., Kiebler, M.,... Ninkovic, J. (2019). Choroid plexus-derived miR-204 regulates the number of quiescent neural stem cells in the adult brain. EMBO Journal. https://dx.doi.org/10.15252/embj.2018100481

MLA:
Lepko, Tjasa, et al. "Choroid plexus-derived miR-204 regulates the number of quiescent neural stem cells in the adult brain." EMBO Journal (2019).

BibTeX: 

Last updated on 2019-05-08 at 07:09