Magnetic accumulation of spions under arterial flow conditions: Effect of serum and red blood cells

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Details zur Publikation

Autorinnen und Autoren: Hennig TL, Unterweger H, Lyer S, Alexiou C, Cicha I
Zeitschrift: Molecules
Jahr der Veröffentlichung: 2019
Band: 24
Heftnummer: 14
ISSN: 1420-3049


Abstract

Magnetic drug targeting utilizes an external magnetic field to target superparamagnetic iron oxide nanoparticles (SPIONs) and their cargo to the diseased vasculature regions. In the arteries, the flow conditions affect the behavior of magnetic particles and the efficacy of their accumulation. In order to estimate the magnetic capture of SPIONs in more physiological-like settings, we previously established an ex vivo model based on human umbilical cord arteries. The artery model was employed in our present studies in order to analyze the effects of the blood components on the efficacy of magnetic targeting, utilizing 2 types of SPIONs with different physicochemical characteristics. In the presence of freshly isolated human plasma or whole blood, a strong increase in iron content measured by AES was observed for both particle types along the artery wall, in parallel with clotting activation due to endogenous thrombin generation in plasma. Subsequent studies therefore utilized SPION suspensions in serum and washed red blood cells (RBCs) at hematocrit 50%. Interestingly, in contrast to cell culture medium suspensions, magnetic accumulation of circulating SPION-3 under the external magnet was achieved in the presence of RBCs. Taken together, our data shows that the presence of blood components affects, but does not prevent, the magnetic accumulation of circulating SPIONs.


FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Alexiou, Christoph Prof. Dr.
Professur für Nanomedizin
Cicha, Iwona Prof. Dr.
Medizinische Fakultät
Lyer, Stefan Dr. rer. nat.
Hals-Nasen-Ohren-Klinik - Kopf- und Halschirurgie
Unterweger, Harald Dr.-Ing.
Hals-Nasen-Ohren-Klinik - Kopf- und Halschirurgie


Zitierweisen

APA:
Hennig, T.L., Unterweger, H., Lyer, S., Alexiou, C., & Cicha, I. (2019). Magnetic accumulation of spions under arterial flow conditions: Effect of serum and red blood cells. Molecules, 24(14). https://dx.doi.org/10.3390/molecules24142588

MLA:
Hennig, Till L., et al. "Magnetic accumulation of spions under arterial flow conditions: Effect of serum and red blood cells." Molecules 24.14 (2019).

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Zuletzt aktualisiert 2019-05-08 um 08:38