NLRP6 Deficiency in CD4 T Cells Decreases T Cell Survival Associated with Increased Cell Death

Radulovic K, Ayata CK, Mak'Anyengo R, Lechner K, Wuggenig P, Kaya B, Hruz P, De Aguero MG, Broz P, Weigmann B, Niess JH (2019)

Publication Type: Journal article

Publication year: 2019

Journal

Journal of Immunology American Association of Immunologists

Book Volume: 203

Pages Range: 544-556

Journal Issue: 2

DOI: 10.4049/jimmunol.1800938

Abstract

The nucleotide-binding oligomerization domain (NOD)-like receptors belong to the family of pattern recognition receptors (PRRs). NOD-like receptors play a role in regulation of innate immune response by recognition of both pathogen-associated molecular patterns that are engulfed during phagocytic process and danger-associated molecular patterns that are mainly byproducts of cell stress mediated response. NOD-like family pyrin domain containing 6 (NLRP6) is one of the 14 pyrin domain-containing receptors. NLRP6 is highly expressed by epithelial and goblet cells to regulate epithelial renewal and mucus production in mice and humans, but its function in T cells is rather unknown. Increased caspase-1 activation and cell death were observed in mouse Nlrp6-deficient T cells following adoptive transfer into Rag2-deficient mice, indicating that Nlrp6 deficiency in CD4(+) T cells led to decreased survival.

Authors with CRIS profile

Benno Weigmann Medizinische Fakultät

Involved external institutions

Universitätsklinikum Heidelberg DE Germany (DE) Universität Basel CH Switzerland (CH) Université de Lausanne (UNIL) CH Switzerland (CH) Universität Bern CH Switzerland (CH) St. Claraspital AG CH Switzerland (CH)

How to cite

APA:

Radulovic, K., Ayata, C.K., Mak'Anyengo, R., Lechner, K., Wuggenig, P., Kaya, B.,... Niess, J.H. (2019). NLRP6 Deficiency in CD4 T Cells Decreases T Cell Survival Associated with Increased Cell Death. Journal of Immunology, 203(2), 544-556. https://dx.doi.org/10.4049/jimmunol.1800938

MLA:

Radulovic, Katarina, et al. "NLRP6 Deficiency in CD4 T Cells Decreases T Cell Survival Associated with Increased Cell Death." Journal of Immunology 203.2 (2019): 544-556.

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