Relevance of receptor for advanced glycation end products (RAGE) in murine antibody-mediated autoimmune diseases

Journal article


Publication Details

Author(s): Eichhorst A, Daniel C, Rzepka R, Sehnert B, Nimmerjahn F, Voll RE, Chevalier N
Journal: International Journal of Molecular Sciences
Publication year: 2019
Volume: 20
Journal issue: 13
ISSN: 1422-0067


Abstract

It is incompletely understood how self-antigens become targets of humoral immunity in antibody-mediated autoimmune diseases. In this context, alarmins are discussed as an important level of regulation. Alarmins are recognized by various receptors, such as receptor for advanced glycation end products (RAGE). As RAGE is upregulated under inflammatory conditions, strongly binds nucleic acids and mediates pro-inflammatory responses upon alarmin recognition, our aim was to examine its contribution to immune complex-mediated autoimmune diseases. This question was addressed employing RAGE−/− animals in murine models of pristane-induced lupus, collagen-induced, and serum-transfer arthritis. Autoantibodies were assessed by enzyme-linked immunosorbent assay, renal disease by quantification of proteinuria and histology, arthritis by scoring joint inflammation. The associated immune status was determined by flow cytometry. In both disease entities, we detected tendentiously decreased autoantibody levels in RAGE−/− mice, however no differences in clinical outcome. In accordance with autoantibody levels, a subgroup of the RAGE−/− animals showed a decrease in plasma cells, and germinal center B cells and an increase in follicular B cells. Based on our results, we suggest that RAGE deficiency alone does not significantly affect antibody-mediated autoimmunity. RAGE may rather exert its effects along with other receptors linking environmental factors to auto-reactive immune responses.


FAU Authors / FAU Editors

Daniel, Christoph Prof. Dr.
Nimmerjahn, Falk Prof. Dr.
Nephropathologische Abteilung im Pathologischen Institut
Lehrstuhl für Genetik


External institutions with authors

Albert-Ludwigs-Universität Freiburg


How to cite

APA:
Eichhorst, A., Daniel, C., Rzepka, R., Sehnert, B., Nimmerjahn, F., Voll, R.E., & Chevalier, N. (2019). Relevance of receptor for advanced glycation end products (RAGE) in murine antibody-mediated autoimmune diseases. International Journal of Molecular Sciences, 20(13). https://dx.doi.org/10.3390/ijms20133234

MLA:
Eichhorst, Alexandra, et al. "Relevance of receptor for advanced glycation end products (RAGE) in murine antibody-mediated autoimmune diseases." International Journal of Molecular Sciences 20.13 (2019).

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Last updated on 2019-23-07 at 18:08