Two decades of SPECT/CT – the coming of age of a technology: An updated review of literature evidence
Israel O, Pellet O, Biassoni L, De Palma D, Estrada-Lobato E, Gnanasegaran G, Kuwert T, la Fougère C, Mariani G, Massalha S, Paez D, Giammarile F (2019)
Publication Type: Journal article, Review article
Publication year: 2019
Journal
DOI: 10.1007/s00259-019-04404-6
Abstract
Purpose: Single-photon emission computed tomography (SPECT) combined with computed tomography (CT) was introduced as a hybrid SPECT/CT imaging modality two decades ago. The main advantage of SPECT/CT is the increased specificity achieved through a more precise localization and characterization of functional findings. The improved diagnostic accuracy is also associated with greater diagnostic confidence and better inter-specialty communication. Methods: This review presents a critical assessment of the relevant literature published so far on the role of SPECT/CT in a variety of clinical conditions. It also includes an update on the established evidence demonstrating both the advantages and limitations of this modality. Conclusions: For the majority of applications, SPECT/CT should be a routine imaging technique, fully integrated into the clinical decision-making process, including oncology, endocrinology, orthopaedics, paediatrics, and cardiology. Large-scale prospective studies are lacking, however, on the use of SPECT/CT in certain clinical domains such as neurology and lung disorders. The review also presents data on the complementary role of SPECT/CT with other imaging modalities and a comparative analysis, where available.
Authors with CRIS profile
Involved external institutions
Technion - Israel Institute of Technology
Israel (IL)
International Atomic Energy Agency (IAEA)
Austria (AT)
University College London (UCL)
United Kingdom (GB)
ASST dei Sette Laghi
Italy (IT)
Leeds Teaching Hospitals NHS Trust
United Kingdom (GB)
Universitätsklinikum Tübingen
Germany (DE)
University of Pisa / Università di Pisa (UniPi)
Italy (IT)
University of Ottawa
Canada (CA)
Israel (IL)
International Atomic Energy Agency (IAEA)
Austria (AT)
University College London (UCL)
United Kingdom (GB)
ASST dei Sette Laghi
Italy (IT)
Leeds Teaching Hospitals NHS Trust
United Kingdom (GB)
Universitätsklinikum Tübingen
Germany (DE)
University of Pisa / Università di Pisa (UniPi)
Italy (IT)
University of Ottawa
Canada (CA)
How to cite
APA:
Israel, O., Pellet, O., Biassoni, L., De Palma, D., Estrada-Lobato, E., Gnanasegaran, G.,... Giammarile, F. (2019). Two decades of SPECT/CT – the coming of age of a technology: An updated review of literature evidence. European Journal of Nuclear Medicine and Molecular Imaging. https://dx.doi.org/10.1007/s00259-019-04404-6
MLA:
Israel, Ora, et al. "Two decades of SPECT/CT – the coming of age of a technology: An updated review of literature evidence." European Journal of Nuclear Medicine and Molecular Imaging (2019).
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