Iron surface functionalization system - Iron oxide nanostructured arrays with polycaprolactone coatings: Biodegradation, cytocompatibility, and drug release behavior

Journal article


Publication Details

Author(s): Zhou J, Yang Y, Detsch R, Boccaccini AR, Virtanen S
Journal: Applied Surface Science
Publication year: 2019
Volume: 492
Pages range: 669-682
ISSN: 0169-4332


Abstract

A surface functionalization system targeted for iron-based materials is developed by combining two biodegradable components, iron oxide nanostructured arrays and polycaprolactone (PCL) coatings. Iron oxide nanoporous and nanotubular arrays are superior surface functionalization matrices, while their stability and cytocompatibility can be further improved by PCL coatings, the morphology of which can modify the drug release behavior. The biodegradation behavior of this system was investigated firstly by electrochemical tests, and further biodegradation information (including the surface morphology and chemical composition) was collected from samples used in a long-term in vitro cytocompatibility test over 21 days of incubation with human adipose-derived stem cells (ADSCs). Moreover, the drug release behavior of these arrays coated with various PCL coatings was studied using tetracycline as a model drug. Experimental results demonstrate that PCL coatings can endow iron oxide nanostructured arrays a proper biodegradation behavior with bioactive degradation products on the surface, also leading to high cytocompatibility characterized by the production of collagen type I and cell distribution on the PCL-coated samples. Furthermore, with the barrier effect of PCL, the whole functionalization system shows sustainable drug release behavior.


FAU Authors / FAU Editors

Boccaccini, Aldo R. Prof. Dr.-Ing.
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Detsch, Rainer Dr.-Ing.
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Virtanen, Sannakaisa Prof. Dr.
Professur für Werkstoffwissenschaften (Korrosion und Oberflächentechnik)
Yang, Yuyun
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Zhou, Juncen
Lehrstuhl für Werkstoffwissenschaften (Korrosion und Oberflächentechnik)


How to cite

APA:
Zhou, J., Yang, Y., Detsch, R., Boccaccini, A.R., & Virtanen, S. (2019). Iron surface functionalization system - Iron oxide nanostructured arrays with polycaprolactone coatings: Biodegradation, cytocompatibility, and drug release behavior. Applied Surface Science, 492, 669-682. https://dx.doi.org/10.1016/j.apsusc.2019.06.060

MLA:
Zhou, Juncen, et al. "Iron surface functionalization system - Iron oxide nanostructured arrays with polycaprolactone coatings: Biodegradation, cytocompatibility, and drug release behavior." Applied Surface Science 492 (2019): 669-682.

BibTeX: 

Last updated on 2019-16-07 at 13:23