Influence of patient and tumor characteristics on therapy persistence with letrozole in postmenopausal women with advanced breast cancer: results of the prospective observational EvAluate-TM study

Wallwiener M, Nabieva N, Feisst M, Fehm T, De Waal J, Rezai M, Baier B, Baake G, Kolberg HC, Guggenberger M, Warm M, Harbeck N, Wuerstlein R, Deuker JU, Dall P, Richter B, Wachsmann G, Brucker C, Siebers JW, Popovic M, Kuhn T, Wolf C, Vollert HW, Breitbach GP, Janni W, Landthaler R, Kohls A, Rezek D, Noesselt T, Fischer G, Henschen S, Praetz T, Heyl V, Kuehn T, Krauss T, Thomssen C, Hohn A, Tesch H, Mundhenke C, Hein A, Rauh C, Bayer CM, Schmidt K, Belleville E, Brucker SY, Hadji P, Beckmann M, Wallwiener D, Kuemmel S, Hartkopf A, Fasching P (2019)


Publication Type: Journal article

Publication year: 2019

Journal

Book Volume: 19

DOI: 10.1186/s12885-019-5806-y

Abstract

BackgroundTreatment of postmenopausal, hormone receptor-positive metastatic breast cancer (MBC) patients varies despite clear therapy guidelines, favoring endocrine treatment (ET). Aim of this study was to analyze persistence of palliative aromatase inhibitor (AI) monotherapy in MBC patients.MethodsEvAluate-TM is a prospective, multicenter, noninterventional study to evaluate treatment with letrozole in postmenopausal women with hormone receptor-positive breast cancer. To assess therapy persistence, defined as the time from therapy start to the end of the therapy (TTEOT), two pre-specified study visits took place after 6 and 12months. Competing risk survival analyses were performed to identify patient and tumor characteristics that predict TTEOT.ResultsOut of 200 patients, 66 patients terminated treatment prematurely, 26 (13%) of them due to causes other than disease progression. Persistence rate for reasons other than progression at 12months was 77.7%. Persistence was lower in patients who reported any adverse event (AE) in the first 30days of ET (89.5% with no AE and 56% with AE). Furthermore, patients had a lower persistence if they reported compliance problems in the past before letrozole treatment.ConclusionsDespite suffering from a life-threatening disease, AEs of an AI will result in a relevant number of treatment terminations that are not related to progression. Some subgroups of patients have very low persistence rates. Especially with regard to novel endocrine combination therapies, these data imply that some groups of patients will need special attention to guide them through the therapy process.Trial registrationClinical Trials Number: CFEM345DDE19

Authors with CRIS profile

Involved external institutions

Luisenkrankenhaus Düsseldorf DE Germany (DE) Ruprecht-Karls-Universität Heidelberg DE Germany (DE) Heinrich-Heine-Universität Düsseldorf DE Germany (DE) Eberhard Karls Universität Tübingen DE Germany (DE) Klinikum Landkreis Tuttlingen DE Germany (DE) Onkologische Praxis Pinneberg DE Germany (DE) Universitätsklinikum Köln DE Germany (DE) Kreisklinik Günzburg Krumach DE Germany (DE) Vinzenzkrankenhaus Hannover DE Germany (DE) Marien-Hospital DE Germany (DE) Städtisches Klinikum Lüneburg DE Germany (DE) Evangelisches Krankenhaus Ludwigsfelde-Teltow DE Germany (DE) Marienhospital Bottrop DE Germany (DE) Städtisches Klinikum Neunkirchen DE Germany (DE) Diakonie-Klinikum Stuttgart Diakonissenkrankenhaus und Paulinenhilfe DE Germany (DE) Paracelsus Medizinische Privatuniversität AT Austria (AT) Klinikum Bayreuth DE Germany (DE) Medizinisches Zentrum Ulm DE Germany (DE) Klinikum Friedrichshafen DE Germany (DE) Städtisches Krankenhaus Kiel DE Germany (DE) Krankenhaus Nordwest DE Germany (DE) ClinSol GmbH & Co.KG DE Germany (DE) Landkreis Mittweida Krankenhaus DE Germany (DE) Novartis Pharma Germany DE Germany (DE) Sana Klinikum Hameln-Pyrmont DE Germany (DE) Centrum für Hämatologie und Onkologie Bethanien DE Germany (DE) Universitätsklinikum Ulm DE Germany (DE) Martin-Luther-Universität Halle-Wittenberg (MLU) DE Germany (DE) Johanniter-Krankenhaus Genthin-Stendal DE Germany (DE) Klinikum der Universität München (Großhadern und Innenstadt) DE Germany (DE) Elblandkliniken DE Germany (DE) Asklepios Klinik Wiesbaden DE Germany (DE) Caritas-Krankenhaus Bad Mergentheim gemeinnützige GmbH DE Germany (DE) Universitätsklinikum Schleswig-Holstein (UKSH) DE Germany (DE)

How to cite

APA:

Wallwiener, M., Nabieva, N., Feisst, M., Fehm, T., De Waal, J., Rezai, M.,... Fasching, P. (2019). Influence of patient and tumor characteristics on therapy persistence with letrozole in postmenopausal women with advanced breast cancer: results of the prospective observational EvAluate-TM study. BMC Cancer, 19. https://dx.doi.org/10.1186/s12885-019-5806-y

MLA:

Wallwiener, Markus, et al. "Influence of patient and tumor characteristics on therapy persistence with letrozole in postmenopausal women with advanced breast cancer: results of the prospective observational EvAluate-TM study." BMC Cancer 19 (2019).

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