Potential Use of Gluconate in Cancer Therapy

Mycielska ME, Mohr MTJ, Schmidt K, Drexler K, Ruemmele P, Haferkamp S, Schlitt HJ, Gaumann A, Adamski J, Geissler EK (2019)

Publication Type: Journal article

Publication year: 2019

Journal

Frontiers in Oncology Frontiers Media

Book Volume: 9

DOI: 10.3389/fonc.2019.00522

Abstract

We have recently discovered that cancer cells take up extracellular citrate through plasma membrane citrate transporter (pmCiC) and advantageously use citrate for their metabolism. Citrate uptake can be blocked with gluconate and this results in decreased tumor growth and altered metabolic characteristics of tumor tissue. Interestingly, gluconate, considered to be physiologically neutral, is incidentally used in medicine as a cation carrier, but not as a therapeutically active substance. In this review we discuss the results of our recent research with available literature and suggest that gluconate may be useful in the treatment of cancer.

Involved external institutions

Universitätsklinikum Regensburg DE Germany (DE) Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (HMGU) / Helmholtz Munich DE Germany (DE) Institut für Pathologie Kaufbeuren-Ravensburg GbR DE Germany (DE)

How to cite

APA:

Mycielska, M.E., Mohr, M.T.J., Schmidt, K., Drexler, K., Ruemmele, P., Haferkamp, S.,... Geissler, E.K. (2019). Potential Use of Gluconate in Cancer Therapy. Frontiers in Oncology, 9. https://dx.doi.org/10.3389/fonc.2019.00522

MLA:

Mycielska, Maria E., et al. "Potential Use of Gluconate in Cancer Therapy." Frontiers in Oncology 9 (2019).

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