Exploration of new contrasts, targets, and MR imaging and spectroscopy techniques for neuromuscular disease-A workshop report of working group 3 of the biomedicine and molecular biosciences COST action BM1304 MYO-MRI

Strijkers GJ, Araujo EC, Azzabou N, Bendahan D, Blamire A, Burakiewicz J, Carlier PG, Damon B, Deligianni X, Froeling M, Heerschap A, Hollingsworth KG, Hooijmans MT, Karampinos DC, Loudos G, Madelin G, Marty B, Nagel AM, Nederveen AJ, Nelissen JL, Santini F, Scheidegger O, Schick F, Sinclair C, Sinkus R, De Sousa PL, Straub V, Walter G, Kan HE (2019)

Publication Type: Journal article, Review article

Publication year: 2019

Journal

Book Volume: 6

Pages Range: 1-30

Journal Issue: 1

DOI: 10.3233/JND-180333

Abstract

Neuromuscular diseases are characterized by progressive muscle degeneration and muscle weakness resulting in functional disabilities. While each of these diseases is individually rare, they are common as a group, and a large majority lacks effective treatment with fully market approved drugs. Magnetic resonance imaging and spectroscopy techniques (MRI and MRS) are showing increasing promise as an outcome measure in clinical trials for these diseases. In 2013, the European Union funded the COST (co-operation in science and technology) action BM1304 called MYO-MRI (www.myo-mri.eu), with the overall aim to advance novel MRI and MRS techniques for both diagnosis and quantitative monitoring of neuromuscular diseases through sharing of expertise and data, joint development of protocols, opportunities for young researchers and creation of an online atlas of muscle MRI and MRS. In this report, the topics that were discussed in the framework of working group 3, which had the objective to: Explore new contrasts, new targets and new imaging techniques for NMD are described. The report is written by the scientists who attended the meetings and presented their data. An overview is given on the different contrasts that MRI can generate and their application, clinical needs and desired readouts, and emerging methods.

Authors with CRIS profile

Involved external institutions

University of Amsterdam Netherlands (NL) King’s College London United Kingdom (GB) BioEmission Technology Solutions Greece (GR) UCL Institute of Neurology United Kingdom (GB) Inselspital, Universitätsspital Bern Switzerland (CH) New York University (NYU) United States (USA) (US) Technische Universität München (TUM) Germany (DE) Radboud University Nijmegen Medical Centre / Radboudumc of voluit Radboud Universitair Medisch Centrum (UMC) Netherlands (NL) Université de Strasbourg (UDS) France (FR) Universitätsspital Basel Switzerland (CH) Newcastle University United Kingdom (GB) French Alternative Energies and Atomic Energy Commission (CEA) France (FR) Eberhard Karls Universität Tübingen Germany (DE) Leiden University Medical Center Netherlands (NL) University of Florida United States (USA) (US) Aix-Marseille University / Aix-Marseille Université France (FR) Vanderbilt University United States (USA) (US) University Medical Centre Utrecht (UMC Utrecht) Netherlands (NL)

How to cite

APA:

Strijkers, G.J., Araujo, E.C., Azzabou, N., Bendahan, D., Blamire, A., Burakiewicz, J.,... Kan, H.E. (2019). Exploration of new contrasts, targets, and MR imaging and spectroscopy techniques for neuromuscular disease-A workshop report of working group 3 of the biomedicine and molecular biosciences COST action BM1304 MYO-MRI. Journal of Neuromuscular Diseases, 6(1), 1-30. https://dx.doi.org/10.3233/JND-180333

MLA:

Strijkers, Gustav J., et al. "Exploration of new contrasts, targets, and MR imaging and spectroscopy techniques for neuromuscular disease-A workshop report of working group 3 of the biomedicine and molecular biosciences COST action BM1304 MYO-MRI." Journal of Neuromuscular Diseases 6.1 (2019): 1-30.

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