Studies on Pd(1,4-bis(2-hydroxyethyl)piperazine)-dicarboxylic acid complexes as models for carboplatin with structural features enhancing the interaction with DNA
Shehata MR, Shoukry MM, Mabrouk MA, Kozakiewicz A, van Eldik R (2019)
Publication Type: Journal article
Publication year: 2019
Journal
DOI: 10.1080/00958972.2019.1632441
Abstract
[Pd(BHEP)Cl2] and [Pd(BHEP)(CBDA)] complexes, where BHEP = 1,4-bis(2-hydroxyethyl)piperazine and CBDA = cyclobutanedicarboxylate, were synthesized and characterized. [Pd(BHEP) (CBDA)] crystallizes in space group P21, a = 9.5740(8) Å, b = 9.4700(7) Å, c = 9.7890(10) Å, α = 90.00°, β = 113.360(5)°, γ = 90.00°, V = 814.78(13) Å3, Z = 2. The palladium center has a typical square planar geometry with tetrahedral distortion. DFT calculations show good agreement between theoretical and X-ray data. The stability constants and stoichiometry of the complexes formed between various dicarboxylic acids and [Pd(BHEP)(H2O)2]2+ were studied. Dicarboxylic acids form 1:1 and protonated complexes. Inosine forms 1:1, 1:2 and the protonated form of 1:1 complexes. The temperature effect on the formation constant of the cyclobutanedicarboxylate complex was investigated. The hydrolysis of [Pd(BHEP)(H2O)2]2+ and complex formation with cyclobutanedicarboxylic acid are exothermic processes.
Authors with CRIS profile
Involved external institutions
Cairo University
Egypt (EG)
Ministry of Defence and Military Production
Egypt (EG)
Nicolaus Copernicus University (NCU) / Uniwersytet Mikołaja Kopernika w Toruniu (UMK)
Poland (PL)
Egypt (EG)
Ministry of Defence and Military Production
Egypt (EG)
Nicolaus Copernicus University (NCU) / Uniwersytet Mikołaja Kopernika w Toruniu (UMK)
Poland (PL)
How to cite
APA:
Shehata, M.R., Shoukry, M.M., Mabrouk, M.A., Kozakiewicz, A., & van Eldik, R. (2019). Studies on Pd(1,4-bis(2-hydroxyethyl)piperazine)-dicarboxylic acid complexes as models for carboplatin with structural features enhancing the interaction with DNA. Journal of Coordination Chemistry. https://dx.doi.org/10.1080/00958972.2019.1632441
MLA:
Shehata, Mohamed R., et al. "Studies on Pd(1,4-bis(2-hydroxyethyl)piperazine)-dicarboxylic acid complexes as models for carboplatin with structural features enhancing the interaction with DNA." Journal of Coordination Chemistry (2019).
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