Studies on Pd(1,4-bis(2-hydroxyethyl)piperazine)-dicarboxylic acid complexes as models for carboplatin with structural features enhancing the interaction with DNA

Journal article


Publication Details

Author(s): Shehata MR, Shoukry MM, Mabrouk MA, Kozakiewicz A, van Eldik R
Journal: Journal of Coordination Chemistry
Publication year: 2019
ISSN: 0095-8972
eISSN: 1029-0389


Abstract

[Pd(BHEP)Cl2] and [Pd(BHEP)(CBDA)] complexes, where BHEP = 1,4-bis(2-hydroxyethyl)piperazine and CBDA = cyclobutanedicarboxylate, were synthesized and characterized. [Pd(BHEP) (CBDA)] crystallizes in space group P21, a = 9.5740(8) Å, b = 9.4700(7) Å, c = 9.7890(10) Å, α = 90.00°, β = 113.360(5)°, γ = 90.00°, V = 814.78(13) Å3, Z = 2. The palladium center has a typical square planar geometry with tetrahedral distortion. DFT calculations show good agreement between theoretical and X-ray data. The stability constants and stoichiometry of the complexes formed between various dicarboxylic acids and [Pd(BHEP)(H2O)2]2+ were studied. Dicarboxylic acids form 1:1 and protonated complexes. Inosine forms 1:1, 1:2 and the protonated form of 1:1 complexes. The temperature effect on the formation constant of the cyclobutanedicarboxylate complex was investigated. The hydrolysis of [Pd(BHEP)(H2O)2]2+ and complex formation with cyclobutanedicarboxylic acid are exothermic processes.


FAU Authors / FAU Editors

van Eldik, Rudi Prof. Dr.
Naturwissenschaftliche Fakultät


External institutions with authors

Cairo University
Ministry of Defence and Military Production
Nicolaus Copernicus University / Uniwersytet Mikołaja Kopernika w Toruniu (UMK)


How to cite

APA:
Shehata, M.R., Shoukry, M.M., Mabrouk, M.A., Kozakiewicz, A., & van Eldik, R. (2019). Studies on Pd(1,4-bis(2-hydroxyethyl)piperazine)-dicarboxylic acid complexes as models for carboplatin with structural features enhancing the interaction with DNA. Journal of Coordination Chemistry. https://dx.doi.org/10.1080/00958972.2019.1632441

MLA:
Shehata, Mohamed R., et al. "Studies on Pd(1,4-bis(2-hydroxyethyl)piperazine)-dicarboxylic acid complexes as models for carboplatin with structural features enhancing the interaction with DNA." Journal of Coordination Chemistry (2019).

BibTeX: 

Last updated on 2019-16-07 at 08:38