Gata6+ Pericardial Cavity Macrophages Relocate to the Injured Heart and Prevent Cardiac Fibrosis

Beitrag in einer Fachzeitschrift


Details zur Publikation

Autorinnen und Autoren: Deniset JF, Belke D, Lee WY, Jorch SK, Deppermann C, Hassanabad AF, Turnbull JD, Teng G, Rozich I, Hudspeth K, Kanno Y, Brooks SR, Hadjantonakis AK, O'Shea JJ, Weber G, Fedak PW, Kubes P
Zeitschrift: Immunity
Jahr der Veröffentlichung: 2019
ISSN: 1074-7613


Abstract

Macrophages play an important role in structural cardiac remodeling and the transition to heart failure following myocardial infarction (MI). Previous research has focused on the impact of blood-derived monocytes on cardiac repair. Here we examined the contribution of resident cavity macrophages located in the pericardial space adjacent to the site of injury. We found that disruption of the pericardial cavity accelerated maladaptive post-MI cardiac remodeling. Gata6+ macrophages in mouse pericardial fluid contributed to the reparative immune response. Following experimental MI, these macrophages invaded the epicardium and lost Gata6 expression but continued to perform anti-fibrotic functions. Loss of this specialized macrophage population enhanced interstitial fibrosis after ischemic injury. Gata6+ macrophages were present in human pericardial fluid, supporting the notion that this reparative function is relevant in human disease. Our findings uncover an immune cardioprotective role for the pericardial tissue compartment and argue for the reevaluation of surgical procedures that remove the pericardium. Deniset et al. describe the pericardial cavity as an important source of resident macrophages that migrate into the heart following ischemic injury and prevent detrimental repair caused by excessive fibrosis.


Einrichtungen weiterer Autorinnen und Autoren

Memorial Sloan Kettering Cancer Center
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
University of Calgary
US National Institutes of Health (NIH)


Zitierweisen

APA:
Deniset, J.F., Belke, D., Lee, W.Y., Jorch, S.K., Deppermann, C., Hassanabad, A.F.,... Kubes, P. (2019). Gata6+ Pericardial Cavity Macrophages Relocate to the Injured Heart and Prevent Cardiac Fibrosis. Immunity. https://dx.doi.org/10.1016/j.immuni.2019.06.010

MLA:
Deniset, Justin F., et al. "Gata6+ Pericardial Cavity Macrophages Relocate to the Injured Heart and Prevent Cardiac Fibrosis." Immunity (2019).

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Zuletzt aktualisiert 2019-22-07 um 22:08