Extracellular DNA traps in inflammation, injury and healing

Journal article
(Review article)

Publication Details

Author(s): Daniel C, Leppkes M, Munoz LE, Muñoz LE, Schley G, Schett G, Herrmann M
Journal: Nature Reviews Nephrology
Publication year: 2019
ISSN: 1759-5061


Following strong activation signals, several types of immune cells reportedly release chromatin and granular proteins into the extracellular space, forming DNA traps. This process is especially prominent in neutrophils but also occurs in other innate immune cells such as macrophages, eosinophils, basophils and mast cells. Initial reports demonstrated that extracellular traps belong to the bactericidal and anti-fungal armamentarium of leukocytes, but subsequent studies also linked trap formation to a variety of human diseases. These pathological roles of extracellular DNA traps are now the focus of intensive biomedical research. The type of pathology associated with the release of extracellular DNA traps is mainly determined by the site of trap formation and the way in which these traps are further processed. Targeting the formation of aberrant extracellular DNA traps or promoting their efficient clearance are attractive goals for future therapeutic interventions, but the manifold actions of extracellular DNA traps complicate these approaches.

FAU Authors / FAU Editors

Daniel, Christoph Prof. Dr.
Nephropathologische Abteilung im Pathologischen Institut
Herrmann, Martin Prof. Dr.
Medizinische Klinik 3 - Rheumatologie und Immunologie
Schett, Georg Prof. Dr. med.
Lehrstuhl für Innere Medizin III

How to cite

Daniel, C., Leppkes, M., Munoz, L.E., Muñoz, L.E., Schley, G., Schett, G., & Herrmann, M. (2019). Extracellular DNA traps in inflammation, injury and healing. Nature Reviews Nephrology. https://dx.doi.org/10.1038/s41581-019-0163-2

Daniel, Christoph, et al. "Extracellular DNA traps in inflammation, injury and healing." Nature Reviews Nephrology (2019).


Last updated on 2019-12-07 at 12:53