Protecting the esophagus from thermal injury during radiofrequency ablation with an esophageal cooling device
Montoya MM, Mickelsen S, Clark B, Hanks J, Sauter E, Kulstad E, Arnold M (2019)
Publication Type: Journal article
Publication year: 2019
Journal
Book Volume: 11
Journal Issue: 5
DOI: 10.4022/jafib.2110
Abstract
Purpose: We sought to quantify the capabilities of a commercially available cooling device to protect the esophagus from RF injury in an animal model and develop a mathematical model to describe the system and provide a framework from which to advance this technology. Methods: A series of ablations (10 W, duration 30-45 seconds) were performed directly on exposed swine esophagus. Control ablations were performed with static 37°C water, and treatment ablations were performed with water (range 5°C-37°C) circulating within the device. Mucosal lesions were evaluated visually and with target tissue histology. A mathematical model was then developed and compared against the experimental data. Results: All 23 ablations (100%) performed under control conditions produced visible external esophageal lesions; 12 of these (52%) were transmural. Under treatment conditions, only 5 of 23 ablations (22%) produced visible external lesions; none (0%) were transmural. Transmurality of lesions decreased as circulating water temperature decreased, with absolute reduction ranging from 5.1% with the use of 37°C water (p=0.7) to 44.5% with the use of 5°C water (p<0.001). Comparison to the mathematical model showed an R2 of 0.75, representing good agreement. Conclusions: Under worst-case conditions, with RF energy applied directly to the adventitial side of the esophagus, internal esophageal cooling with an esophageal cooling device provides significant protective effect from thermal injury. A mathematical model of the process provides a means to further investigate this approach to preventing esophageal injury during RF ablation and can serve to guide ongoing clinical investigations currently in progress.
Authors with CRIS profile
Involved external institutions
University of Texas Southwestern Medical Center (UT Southwestern)
United States (USA) (US)
University of Iowa
United States (USA) (US)
St. Vincent Indianapolis
United States (USA) (US)
Riverside Medical Center
United States (USA) (US)
Universidad de Antioquía (UDEA)
Colombia (CO)
United States (USA) (US)
University of Iowa
United States (USA) (US)
St. Vincent Indianapolis
United States (USA) (US)
Riverside Medical Center
United States (USA) (US)
Universidad de Antioquía (UDEA)
Colombia (CO)
How to cite
APA:
Montoya, M.M., Mickelsen, S., Clark, B., Hanks, J., Sauter, E., Kulstad, E., & Arnold, M. (2019). Protecting the esophagus from thermal injury during radiofrequency ablation with an esophageal cooling device. Journal of Atrial Fibrillation, 11(5). https://dx.doi.org/10.4022/jafib.2110
MLA:
Montoya, Marcela Mercado, et al. "Protecting the esophagus from thermal injury during radiofrequency ablation with an esophageal cooling device." Journal of Atrial Fibrillation 11.5 (2019).
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