Challenges and perspectives in brain tissue testing and modeling

Journal article
(Original article)


Publication Details

Author(s): Budday S, Holzapfel GA, Steinmann P, Kuhl E
Editor(s): Poceedings in Applied Mathematics and Mechanics
Journal: Proceedings in Applied Mathematics and Mechanics
Publisher: WILEY-VCH Verlag GmbH & Co. KGaA
Publishing place: Weinheim
Publication year: 2019
Volume: accepted
Conference Proceedings Title: accepted
ISSN: 1617-7061


Abstract











While long underestimated, more and more evidence confirms that mechanics play a critical role for brain function and
dysfunction. Therefore, computational simulations based on the field equations of nonlinear continuum mechanics can provide
important insights into the underlying mechanisms of brain injury and disease. Realistic numerical predictions, however,
require models capable of capturing the complex and unique mechanical behavior of this ultrasoft, highly heterogeneous and
adaptive tissue. In recent years, contradictory experimental results have retarded progress in this field. Here, we summarize
the key characteristics of brain tissue behavior on different length and time scales and propose application-specific modeling
approaches, which are as complex as necessary but as simple as possible. The presented considerations will, on the one
hand, facilitate well-designed future experiments and, on the other hand, help to choose the appropriate constitutive law for a
specific application.





FAU Authors / FAU Editors

Budday, Silvia Dr.-Ing.
Lehrstuhl für Technische Mechanik
Steinmann, Paul Prof. Dr.-Ing.
Lehrstuhl für Technische Mechanik


External institutions with authors

Stanford University
Technische Universität Graz


How to cite

APA:
Budday, S., Holzapfel, G.A., Steinmann, P., & Kuhl, E. (2019). Challenges and perspectives in brain tissue testing and modeling. Proceedings in Applied Mathematics and Mechanics, accepted.

MLA:
Budday, Silvia, et al. "Challenges and perspectives in brain tissue testing and modeling." Proceedings in Applied Mathematics and Mechanics accepted (2019).

BibTeX: 

Last updated on 2019-01-07 at 08:53