The expanding functional roles and signaling mechanisms of adhesion G protein–coupled receptors

Journal article


Publication Details

Author(s): Morgan RK, Anderson GR, Araç D, Aust G, Balenga N, Boucard A, Bridges JP, Engel F, Formstone CJ, Glitsch MD, Gray RS, Hall RA, Hsiao CC, Kim HY, Knierim AB, Kusuluri DK, Leon K, Liebscher I, Piao X, Prömel S, Scholz N, Srivastava S, Thor D, Tolias KF, Ushkaryov YA, Vallon M, Van Meir EG, Vanhollebeke B, Wolfrum U, Wright KM, Monk KR, Mogha A
Journal: Annals of the New York Academy of Sciences
Publisher: Blackwell Publishing Inc.
Publication year: 2019
ISSN: 0077-8923
eISSN: 1749-6632


Abstract

The adhesion class of G protein–coupled receptors (GPCRs) is the second largest family of GPCRs (33 members in humans). Adhesion GPCRs (aGPCRs) are defined by a large extracellular N-terminal region that is linked to a C-terminal seven transmembrane (7TM) domain via a GPCR-autoproteolysis inducing (GAIN) domain containing a GPCR proteolytic site (GPS). Most aGPCRs undergo autoproteolysis at the GPS motif, but the cleaved fragments stay closely associated, with the N-terminal fragment (NTF) bound to the 7TM of the C-terminal fragment (CTF). The NTFs of most aGPCRs contain domains known to be involved in cell–cell adhesion, while the CTFs are involved in classical G protein signaling, as well as other intracellular signaling. In this workshop report, we review the most recent findings on the biology, signaling mechanisms, and physiological functions of aGPCRs.


FAU Authors / FAU Editors

Engel, Felix Prof. Dr. rer. nat.
Professur für Experimentelle Nieren- und Kreislaufforschung


External institutions with authors

Baylor College of Medicine
Center for Research and Advanced Studies of the National Polytechnic Institute / Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN)
Emory University
Johannes Gutenberg-Universität Mainz
King’s College London
Medway School of Pharmacy
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Oregon Health and Science University (OSHU)
Stanford University
Universität Leipzig
Université libre de Bruxelles (ULB)
University of Amsterdam
University of California, Riverside (UCR)
University of California San Francisco (UCSF)
University of Chicago
University of Cincinnati
University of Maryland School of Pharmacy
University of Oxford
University of Texas at Austin


How to cite

APA:
Morgan, R.K., Anderson, G.R., Araç, D., Aust, G., Balenga, N., Boucard, A.,... Mogha, A. (2019). The expanding functional roles and signaling mechanisms of adhesion G protein–coupled receptors. Annals of the New York Academy of Sciences. https://dx.doi.org/10.1111/nyas.14094

MLA:
Morgan, Rory K., et al. "The expanding functional roles and signaling mechanisms of adhesion G protein–coupled receptors." Annals of the New York Academy of Sciences (2019).

BibTeX: 

Last updated on 2019-10-07 at 11:08