The expanding functional roles and signaling mechanisms of adhesion G protein–coupled receptors

Morgan RK, Anderson GR, Araç D, Aust G, Balenga N, Boucard A, Bridges JP, Engel F, Formstone CJ, Glitsch MD, Gray RS, Hall RA, Hsiao CC, Kim HY, Knierim AB, Kusuluri DK, Leon K, Liebscher I, Piao X, Prömel S, Scholz N, Srivastava S, Thor D, Tolias KF, Ushkaryov YA, Vallon M, Van Meir EG, Vanhollebeke B, Wolfrum U, Wright KM, Monk KR, Mogha A (2019)

Publication Type: Journal article

Publication year: 2019

Journal

Publisher: Blackwell Publishing Inc.

DOI: 10.1111/nyas.14094

Abstract

The adhesion class of G protein–coupled receptors (GPCRs) is the second largest family of GPCRs (33 members in humans). Adhesion GPCRs (aGPCRs) are defined by a large extracellular N-terminal region that is linked to a C-terminal seven transmembrane (7TM) domain via a GPCR-autoproteolysis inducing (GAIN) domain containing a GPCR proteolytic site (GPS). Most aGPCRs undergo autoproteolysis at the GPS motif, but the cleaved fragments stay closely associated, with the N-terminal fragment (NTF) bound to the 7TM of the C-terminal fragment (CTF). The NTFs of most aGPCRs contain domains known to be involved in cell–cell adhesion, while the CTFs are involved in classical G protein signaling, as well as other intracellular signaling. In this workshop report, we review the most recent findings on the biology, signaling mechanisms, and physiological functions of aGPCRs.

Authors with CRIS profile

Involved external institutions

University of Chicago United States (USA) (US) Universität Leipzig Germany (DE) Baylor College of Medicine United States (USA) (US) Emory University United States (USA) (US) Oregon Health and Science University (OSHU) United States (USA) (US) Medway School of Pharmacy United Kingdom (GB) University of California San Francisco (UCSF) United States (USA) (US) King’s College London United Kingdom (GB) University of California, Riverside (UCR) United States (USA) (US) Stanford University United States (USA) (US) Johannes Gutenberg-Universität Mainz (JGU) Germany (DE) Center for Research and Advanced Studies of the National Polytechnic Institute / Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN) Mexico (MX) University of Amsterdam Netherlands (NL) University of Maryland School of Pharmacy United States (USA) (US) University of Oxford United Kingdom (GB) National Institute on Alcohol Abuse and Alcoholism (NIAAA) Germany (DE) University of Texas at Austin United States (USA) (US) Université libre de Bruxelles (ULB) / Free University of Brussels Belgium (BE) University of Cincinnati United States (USA) (US)

How to cite

APA:

Morgan, R.K., Anderson, G.R., Araç, D., Aust, G., Balenga, N., Boucard, A.,... Mogha, A. (2019). The expanding functional roles and signaling mechanisms of adhesion G protein–coupled receptors. Annals of the New York Academy of Sciences. https://dx.doi.org/10.1111/nyas.14094

MLA:

Morgan, Rory K., et al. "The expanding functional roles and signaling mechanisms of adhesion G protein–coupled receptors." Annals of the New York Academy of Sciences (2019).

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