Diagnosis and Therapy of Triple-Negative Breast Cancer (TNBC) - Recommendations for Daily Routine Practice

Schneeweiss A, Denkert C, Fasching P, Fremd C, Gluz O, Kolberg-Liedtke C, Loibl S, Lück HJ (2019)

Publication Type: Journal article

Publication year: 2019

Journal

Geburtshilfe und Frauenheilkunde Georg Thieme Verlag

Book Volume: 79

Pages Range: 605-617

Article Number: 8870285

Journal Issue: 6

DOI: 10.1055/a-0887-0285

Abstract

The rapid increase in knowledge in tumour biology and tumour pathogenesis of triple-negative breast cancer (TNBC) has resulted in new therapeutic approaches and new therapeutic concepts for treatment. For years, TNBC has been considered to be a difficult-to-treat tumour due to its generally aggressive tumour biology and in view of limited therapeutic options. The risk of recurrence and metastasis is higher than in the case of other breast cancer subtypes of the same stage. In addition to surgery and radiation in the curative situation, systemic chemotherapy with anthracyclines and/or taxanes is still the therapy of choice. New therapeutic approaches are based on the knowledge that TNBC is a molecularly very heterogeneous disease. Research groups are working to classify TNBC better and better on a molecular level and use this molecular subtyping as the basis for new therapeutic strategies. The most promising new approaches and considerations regarding the therapy of TNBCs are shown below. In addition, the current therapeutic strategies are discussed using a fictitious case history, taking the current data and the resultant therapeutic consequence into account.

Authors with CRIS profile

Peter Fasching Professur für Translationale Frauenheilkunde und Geburtshilfe

Involved external institutions

Universitätsklinikum Heidelberg DE Germany (DE) Universitätsklinikum Gießen und Marburg (UKGM) DE Germany (DE) Evangelisches Krankenhaus Bethesda DE Germany (DE) Charité - Universitätsmedizin Berlin DE Germany (DE) GBG Forschungs GmbH (German Breast Group) DE Germany (DE) Gynäkologisch-Onkologische Praxis Hannover DE Germany (DE)

How to cite

APA:

Schneeweiss, A., Denkert, C., Fasching, P., Fremd, C., Gluz, O., Kolberg-Liedtke, C.,... Lück, H.J. (2019). Diagnosis and Therapy of Triple-Negative Breast Cancer (TNBC) - Recommendations for Daily Routine Practice. Geburtshilfe und Frauenheilkunde, 79(6), 605-617. https://dx.doi.org/10.1055/a-0887-0285

MLA:

Schneeweiss, Andreas, et al. "Diagnosis and Therapy of Triple-Negative Breast Cancer (TNBC) - Recommendations for Daily Routine Practice." Geburtshilfe und Frauenheilkunde 79.6 (2019): 605-617.

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