Diagnosis of obstructive coronary artery disease using computed tomography angiography in patients with stable chest pain depending on clinical probability and in clinically important subgroups: Meta-analysis of individual patient data

Journal article

Publication Details

Author(s): Haase R, Schlattmann P, Gueret P, Andreini D, Pontone G, Alkadhi H, Hausleiter J, Garcia MJ, Leschka S, Meijboom WB, Zimmermann E, Gerber B, Schoepf UJ, Shabestari AA, Nørgaard BL, Meijs MF, Sato A, Ovrehus KA, Diederichsen AC, Jenkins SM, Knuuti J, Hamdan A, Halvorsen BA, Mendoza-Rodriguez V, Rochitte CE, Rixe J, Wan YL, Langer C, Bettencourt N, Martuscelli E, Ghostine S, Buechel RR, Nikolaou K, Mickley H, Yang L, Zhang Z, Chen MY, Halon DA, Rief M, Sun K, Hirt-Moch B, Niinuma H, Marcus RP, Muraglia S, Jakamy R, Chow BJ, Kaufmann PA, Tardif JC, Nomura C, Kofoed KF, Laissy JP, Arbab-Zadeh A, Kitagawa K, Laham R, Jinzaki M, Hoe J, Rybicki FJ, Scholte A, Paul N, Tan SY, Yoshioka K, Röhle R, Schuetz GM, Schueler S, Coenen MH, Wieske V, Achenbach S, Budoff MJ, Laule M, Newby DE, Dewey M
Journal: British Medical Journal
Publication year: 2019
Volume: 365
ISSN: 0959-8146


Objective To determine whether coronary computed tomography angiography (CTA) should be performed in patients with any clinical probability of coronary artery disease (CAD), and whether the diagnostic performance differs between subgroups of patients. Design Prospectively designed meta-analysis of individual patient data from prospective diagnostic accuracy studies. Data sources Medline, Embase, and Web of Science for published studies. Unpublished studies were identified via direct contact with participating investigators. Eligibility criteria for selecting studies Prospective diagnostic accuracy studies that compared coronary CTA with coronary angiography as the reference standard, using at least a 50% diameter reduction as a cutoff value for obstructive CAD. All patients needed to have a clinical indication for coronary angiography due to suspected CAD, and both tests had to be performed in all patients. Results had to be provided using 2×2 or 3×2 cross tabulations for the comparison of CTA with coronary angiography. Primary outcomes were the positive and negative predictive values of CTA as a function of clinical pretest probability of obstructive CAD, analysed by a generalised linear mixed model; calculations were performed including and excluding non-diagnostic CTA results. The no-treat/treat threshold model was used to determine the range of appropriate pretest probabilities for CTA. The threshold model was based on obtained post-test probabilities of less than 15% in case of negative CTA and above 50% in case of positive CTA. Sex, angina pectoris type, age, and number of computed tomography detector rows were used as clinical variables to analyse the diagnostic performance in relevant subgroups. Results Individual patient data from 5332 patients from 65 prospective diagnostic accuracy studies were retrieved. For a pretest probability range of 7-67%, the treat threshold of more than 50% and the no-treat threshold of less than 15% post-test probability were obtained using CTA. At a pretest probability of 7%, the positive predictive value of CTA was 50.9% (95% confidence interval 43.3% to 57.7%) and the negative predictive value of CTA was 97.8% (96.4% to 98.7%); corresponding values at a pretest probability of 67% were 82.7% (78.3% to 86.2%) and 85.0% (80.2% to 88.9%), respectively. The overall sensitivity of CTA was 95.2% (92.6% to 96.9%) and the specificity was 79.2% (74.9% to 82.9%). CTA using more than 64 detector rows was associated with a higher empirical sensitivity than CTA using up to 64 rows (93.4% v 86.5%, P=0.002) and specificity (84.4% v 72.6%, P<0.001). The area under the receiver-operating-characteristic curve for CTA was 0.897 (0.889 to 0.906), and the diagnostic performance of CTA was slightly lower in women than in with men (area under the curve 0.874 (0.858 to 0.890) v 0.907 (0.897 to 0.916), P<0.001). The diagnostic performance of CTA was slightly lower in patients older than 75 (0.864 (0.834 to 0.894), P=0.018 v all other age groups) and was not significantly influenced by angina pectoris type (typical angina 0.895 (0.873 to 0.917), atypical angina 0.898 (0.884 to 0.913), non-anginal chest pain 0.884 (0.870 to 0.899), other chest discomfort 0.915 (0.897 to 0.934)). Conclusions In a no-treat/treat threshold model, the diagnosis of obstructive CAD using coronary CTA in patients with stable chest pain was most accurate when the clinical pretest probability was between 7% and 67%. Performance of CTA was not influenced by the angina pectoris type and was slightly higher in men and lower in older patients. Systematic review registration PROSPERO CRD42012002780.

FAU Authors / FAU Editors

Achenbach, Stephan Prof. Dr. med.
Medizinische Klinik 2 - Kardiologie, Angiologie

External institutions with authors

Aarhus University Hospital / Aarhus Universitetshospital
Albert Einstein College of Medicine
Baotou Central Hospital
Beijing Anzhen Hospital
Carmel Medical Center
Centro Cardiologico Monzino (IRCCS)
Centro Hospitalar Vila Nova de Gaia
Chang Gung University (CGU) / 長庚大學
Charité - Universitätsmedizin Berlin
Cliniques universitaires Saint-Luc (CHU St-Luc)
Erasmus University Medical Center (MC)
Glasgow Royal Infirmary (GRI)
HCor - Hospital do Coração, São Paulo, Brasil
Hôpital Bichat-Claude-Bernard (CHU, APHP)
Hôpital Marie Lannelongue
Hospital Israelita Albert Einstein
Hospital Universitário de Mie
Institut de Cardiologie de Montréal
Iwate Medical University
Johns Hopkins Hospital
Kantonsspital St.Gallen
Keio University Hospital
Klinikum der Universität München
Leiden University Medical Center
Medical University of South Carolina (MUSC)
Mount Elizabeth Medical Centre
National Heart, Lung, and Blood Institute
National Heart Research Institute Singapore (NHRIS)
national institute of cardiology and cardiovascular surgery
Odense Universitetshospital (OUH)
Ospedale Santa Chiara
Pitié-Salpêtrière University Hospital / Hôpital universitaire Pitié-Salpêtrière
Shahid Beheshti University of Medical Sciences
St. Luke's International Hospital
Sykehuset Østfold
Tel Aviv University
Turku University Hospital / Turun yliopistollinen keskussairaala (TYKS)
Università degli studi di Milano
Università degli Studi di Roma 'Tor Vergata'
Universitätsklinikum Jena
Universitätsklinikum Knappschaftskrankenhaus Bochum
Universitätsklinikum Tübingen
Universitätsspital Zürich (USZ)
University Medical Centre Utrecht (UMC Utrecht)
University of California Los Angeles (UCLA)
University of Copenhagen
University of Edinburgh
University of Ottawa
University of Paris 12 - Val de Marne / Université Paris XII Val de Marne (UPEC)
University of Tsukuba / 筑波大学
Veterans Affairs Healthcare System Boston and Harvard Medical School
Western University

How to cite

Haase, R., Schlattmann, P., Gueret, P., Andreini, D., Pontone, G., Alkadhi, H.,... Dewey, M. (2019). Diagnosis of obstructive coronary artery disease using computed tomography angiography in patients with stable chest pain depending on clinical probability and in clinically important subgroups: Meta-analysis of individual patient data. British Medical Journal, 365. https://dx.doi.org/10.1136/bmj.l1945

Haase, Robert, et al. "Diagnosis of obstructive coronary artery disease using computed tomography angiography in patients with stable chest pain depending on clinical probability and in clinically important subgroups: Meta-analysis of individual patient data." British Medical Journal 365 (2019).


Last updated on 2019-26-06 at 20:08