Modulation of host cell metabolism by T4SS-encoding intracellular pathogens

Hayek I, Berens C, Lührmann A (2019)

Publication Type: Journal article, Review article

Publication year: 2019

Journal

Current Opinion in Microbiology Elsevier

Book Volume: 47

Pages Range: 59-65

DOI: 10.1016/j.mib.2018.11.010

Abstract

Intracellular bacterial pathogens intimately interact with the infected host cell to prevent elimination and to ensure survival. One group of intracellular pathogens, including Coxiella burnetii, Legionella pneumophila, Brucella spp., Anaplasma phagocytophilum, and Ehrlichia chaffeensis, utilizes a type IV secretion system (T4SS) that injects effectors to modulate host cell signalling, vesicular trafficking, autophagy, cell death and transcription to ensure survival [1]. So far, little emphasis has been directed towards understanding how these bacteria manipulate host cell metabolism. This manipulation is not only important for gaining access to nutrients, but also for regulating specific virulence programs [2,3]. Here, we will summarize recent progress made in characterizing the manipulation of host cell metabolism by C. burnetii and other intracellular pathogens utilizing a T4SS.

Authors with CRIS profile

Inaya Hayek Institute of Microbiology – Clinical Microbiology, Immunology and Hygiene Anja Lührmann Institute of Microbiology – Clinical Microbiology, Immunology and Hygiene

Involved external institutions

Friedrich-Loeffler-Institut (FLI), Bundesforschungsinstitut für Tiergesundheit DE Germany (DE)

How to cite

APA:

Hayek, I., Berens, C., & Lührmann, A. (2019). Modulation of host cell metabolism by T4SS-encoding intracellular pathogens. Current Opinion in Microbiology, 47, 59-65. https://dx.doi.org/10.1016/j.mib.2018.11.010

MLA:

Hayek, Inaya, Christian Berens, and Anja Lührmann. "Modulation of host cell metabolism by T4SS-encoding intracellular pathogens." Current Opinion in Microbiology 47 (2019): 59-65.

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