Kalb M, Langheinrich MC, Merkel S, Krautz C, Brunner M, Bénard A, Weber K, Pilarsky C, Grützmann R, Weber G (2019)
Publication Type: Journal article
Publication year: 2019
Book Volume: 11
Article Number: 609
Journal Issue: 5
Background: Excess bodyweight is known to influence the risk of colorectal cancer; however, little evidence exists for the influence of the body mass index (BMI) on the long-term outcome of patients with rectal cancer. Methods: We assessed the impact of the BMI on the risk of local recurrence, distant metastasis and overall-survival in 612 patients between 2003 and 2010 after rectal cancer diagnosis and treatment at the University Hospital Erlangen. A Cox-regression model was used to estimate the hazard ratio and multivariate risk of mortality and distant-metastasis. Median follow up-time was 58 months. Results: Patients with obesity class II or higher (BMI ≥ 35 kg/m2, n = 25) and patients with underweight (BMI < 18.5 kg/m2, n = 5) had reduced overall survival (hazard ratio (HR) = 1.6; 95% confidence interval (CI) 0.9-2.7) as well as higher rates of distant metastases (hazard ratio HR = 1.7; 95% CI 0.9-3.3) as compared to patients with normal bodyweight (18.5 ≤ BMI < 25 kg/m2, n = 209), overweight (25 ≤ BMI <30 kg/m2, n = 257) or obesity class I (30 ≤ BMI >35 kg/m2, n = 102). There were no significant differences for local recurrence. Conclusions: Underweight and excess bodyweight are associated with lower overall survival and higher rates of distant metastasis in patients with rectal cancer.
APA:
Kalb, M., Langheinrich, M.C., Merkel, S., Krautz, C., Brunner, M., Bénard, A.,... Weber, G. (2019). Influence of body mass index on long-term outcome in patients with rectal cancer-a single centre experience. Cancers, 11(5). https://dx.doi.org/10.3390/cancers11050609
MLA:
Kalb, Maximilian, et al. "Influence of body mass index on long-term outcome in patients with rectal cancer-a single centre experience." Cancers 11.5 (2019).
BibTeX: Download