Autotaxin activity predicts transplant-free survival in primary sclerosing cholangitis

Journal article

Publication Details

Author(s): Dhillon AK, Kremer A, Kummen M, Boberg KM, Elferink RP, Karlsen TH, Beuers U, Vesterhus M, Hov JR
Journal: Scientific Reports
Publication year: 2019
Volume: 9
Journal issue: 1
ISSN: 2045-2322


Autotaxin has been associated with liver disease severity and transplant-free survival. This study aimed to validate autotaxin as a biomarker in two cohorts of Norwegian large-duct PSC patients, one discovery panel (n = 165) and one validation panel (n = 87). Serum activity of autotaxin was measured in diluted sera by a fluorometric enzymatic assay. Patients reaching an end-point, liver transplantation or death, (discovery panel: n = 118 [71.5%]; validation panel: n = 35 [40.2%]), showed higher autotaxin activity compared with the other patients, P < 0.001 and P = 0.004, respectively. Kaplan-Meier survival analyses showed a strong association between increasing autotaxin activity and shorter liver transplant-free survival (discovery panel: P < 0.001, validation panel: P = 0.001). There was no relationship between autotaxin activity and the presence of inflammatory bowel disease or occurrence of hepatobiliary malignancy. In a multivariable analysis, high autotaxin activity was associated with an increased risk of liver transplantation or death (hazard ratio 2.03 (95% confidence interval 1.21–3.40), P < 0.01), independent from Mayo risk score, an in-house enhanced liver fibrosis score and interleukin-8 in serum. In conclusion, increased serum autotaxin activity is associated with reduced liver transplant-free survival independent from Mayo risk score and markers of inflammation and fibrosis.

FAU Authors / FAU Editors

Kremer, Andreas PD Dr.
Medizinische Klinik 1 - Gastroenterologie, Pneumologie und Endokrinologie

External institutions with authors

Amsterdam UMC
Oslo universitetssykehus Rikshospitalet

How to cite

Dhillon, A.K., Kremer, A., Kummen, M., Boberg, K.M., Elferink, R.P., Karlsen, T.H.,... Hov, J.R. (2019). Autotaxin activity predicts transplant-free survival in primary sclerosing cholangitis. Scientific Reports, 9(1).

Dhillon, Amandeep K., et al. "Autotaxin activity predicts transplant-free survival in primary sclerosing cholangitis." Scientific Reports 9.1 (2019).


Last updated on 2019-25-06 at 00:08