Autotaxin activity predicts transplant-free survival in primary sclerosing cholangitis

Dhillon AK, Kremer A, Kummen M, Boberg KM, Elferink RP, Karlsen TH, Beuers U, Vesterhus M, Hov JR (2019)

Publication Type: Journal article

Publication year: 2019

Journal

Scientific Reports Nature Publishing Group: Open Access Journals - Option B

Book Volume: 9

Article Number: 8450

Journal Issue: 1

DOI: 10.1038/s41598-019-44762-7

Abstract

Autotaxin has been associated with liver disease severity and transplant-free survival. This study aimed to validate autotaxin as a biomarker in two cohorts of Norwegian large-duct PSC patients, one discovery panel (n = 165) and one validation panel (n = 87). Serum activity of autotaxin was measured in diluted sera by a fluorometric enzymatic assay. Patients reaching an end-point, liver transplantation or death, (discovery panel: n = 118 [71.5%]; validation panel: n = 35 [40.2%]), showed higher autotaxin activity compared with the other patients, P < 0.001 and P = 0.004, respectively. Kaplan-Meier survival analyses showed a strong association between increasing autotaxin activity and shorter liver transplant-free survival (discovery panel: P < 0.001, validation panel: P = 0.001). There was no relationship between autotaxin activity and the presence of inflammatory bowel disease or occurrence of hepatobiliary malignancy. In a multivariable analysis, high autotaxin activity was associated with an increased risk of liver transplantation or death (hazard ratio 2.03 (95% confidence interval 1.21–3.40), P < 0.01), independent from Mayo risk score, an in-house enhanced liver fibrosis score and interleukin-8 in serum. In conclusion, increased serum autotaxin activity is associated with reduced liver transplant-free survival independent from Mayo risk score and markers of inflammation and fibrosis.

Authors with CRIS profile

Andreas Kremer Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology

Additional Organisation(s)

Interdisziplinäres Zentrum für Klinische Forschung

Involved external institutions

Oslo University Hospital / Oslo Universitetssykehus Rikshospitalet NO Norway (NO) Amsterdam University Medical Centers (Amsterdam UMC) / Amsterdam Universitair Medische Centra NL Netherlands (NL)

How to cite

APA:

Dhillon, A.K., Kremer, A., Kummen, M., Boberg, K.M., Elferink, R.P., Karlsen, T.H.,... Hov, J.R. (2019). Autotaxin activity predicts transplant-free survival in primary sclerosing cholangitis. Scientific Reports, 9(1). https://dx.doi.org/10.1038/s41598-019-44762-7

MLA:

Dhillon, Amandeep K., et al. "Autotaxin activity predicts transplant-free survival in primary sclerosing cholangitis." Scientific Reports 9.1 (2019).

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