Ep400 deficiency in Schwann cells causes persistent expression of early developmental regulators and peripheral neuropathy

Beitrag in einer Fachzeitschrift


Details zur Publikation

Autorinnen und Autoren: Fröb F, Sock E, Tamm ER, Saur AL, Hillgärtner S, Williams TJ, Fujii T, Fukunaga R, Wegner M
Zeitschrift: Nature Communications
Jahr der Veröffentlichung: 2019
Band: 10
ISSN: 2041-1723


Abstract

Schwann cells ensure efficient nerve impulse conduction in the peripheral nervous system. Their development is accompanied by defined chromatin changes, including variant histone deposition and redistribution. To study the importance of variant histones for Schwann cell development, we altered their genomic distribution by conditionally deleting Ep400, the central subunit of the Tip60/Ep400 complex. Ep400 absence causes peripheral neuropathy in mice, characterized by terminal differentiation defects in myelinating and non-myelinating Schwann cells and immune cell activation. Variant histone H2A.Z is differently distributed throughout the genome and remains at promoters of Tfap2a, Pax3 and other transcriptional regulator genes with transient function at earlier developmental stages. Tfap2a deletion in Ep400-deficient Schwann cells causes a partial rescue arguing that continued expression of early regulators mediates the phenotypic defects. Our results show that proper genomic distribution of variant histones is essential for Schwann cell differentiation, and assign importance to Ep400-containing chromatin remodelers in the process.


FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Thiele, Franziska Dr.
Lehrstuhl für Biochemie und Pathobiochemie
Hillgärtner, Simone
Lehrstuhl für Biochemie und Pathobiochemie
Saur, Anna-Lena
Lehrstuhl für Biochemie und Pathobiochemie
Sock, Elisabeth Prof. Dr.
Lehrstuhl für Biochemie und Pathobiochemie
Wegner, Michael Prof. Dr.
Lehrstuhl für Biochemie und Pathobiochemie


Einrichtungen weiterer Autorinnen und Autoren

Osaka University of Pharmaceutical Sciences
Universität Regensburg
University of Colorado System


Zitierweisen

APA:
Fröb, F., Sock, E., Tamm, E.R., Saur, A.-L., Hillgärtner, S., Williams, T.J.,... Wegner, M. (2019). Ep400 deficiency in Schwann cells causes persistent expression of early developmental regulators and peripheral neuropathy. Nature Communications, 10. https://dx.doi.org/10.1038/s41467-019-10287-w

MLA:
Fröb, Franziska, et al. "Ep400 deficiency in Schwann cells causes persistent expression of early developmental regulators and peripheral neuropathy." Nature Communications 10 (2019).

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Zuletzt aktualisiert 2019-20-06 um 00:08