ALIGNed on adherence: subanalysis of adherence in immune-mediated inflammatory diseases in the DACH region of the global ALIGN study

Kolios AGA, Hueber A, Michetti P, Mrowietz U, Mustak-Blagusz M, Sator PG, Reinshagen M, Wilsmann-Theis D, Gomis-Kleindienst S, Luckey U, Roessler A, Schiefke I (2019)

Publication Type: Journal article

Publication year: 2019

Journal

Journal of the European Academy of Dermatology and Venereology Wiley-Blackwell

Book Volume: 33

Pages Range: 234-241

Journal Issue: 1

DOI: 10.1111/jdv.15179

Abstract

Background: Non-adherence to medication is a challenging problem in daily clinical practice. Objective: To assess reasons for non-adherence in patients with chronic immune-mediated inflammatory diseases (IMIDs) in a direct comparison including evaluation of treatment necessity and concerns. Methods: ALIGN was a non-interventional, multicountry, multicentre, self-administered, cross-sectional, epidemiologic survey study. Here, we investigate the German, Austrian and Swiss (DACH) cohort. Six hundred thirty-one patients with different IMIDs (rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, plaque psoriasis, Crohn's disease and ulcerative colitis) under systemic therapies were evaluated concerning adherence, beliefs of necessity and concerns towards treatment in patients with IMIDs. Results: The DACH cohort had significantly different levels of adherence depending on the IMID (P < 0.05) and the type of therapy (P < 0.05). Based on the significant influence of concerns on treatment adherence (P < 0.05) and the high belief of treatment necessity, patients could be classified in four attitudinal segments, which were unequally distributed throughout various IMIDs. High concerns had a significant influence on non-adherence, whereas necessity did not. Older age, female sex, TNFi mono-, conventional combination and TNFi combination therapy are positively associated with adherence. Conclusions: In the DACH region, patients are less concerned about medication and believe in the necessity of treatment. Therefore, we suggest adapting the communication in the various patient groups.

Authors with CRIS profile

Axel Hueber Department of Medicine 3 – Rheumatology and Immunology

Involved external institutions

Universitätsspital Zürich (USZ) CH Switzerland (CH) AbbVie Deutschland GmbH & Co. KG DE Germany (DE) Rehabilitationszentrum Gröbming AT Austria (AT) Lausanne University Hospital / Centre hospitalier universitaire vaudois (CHUV) CH Switzerland (CH) Städtisches Klinikum Braunschweig DE Germany (DE) Universitätsklinikum Schleswig-Holstein (UKSH) DE Germany (DE) Rheinische Friedrich-Wilhelms-Universität Bonn DE Germany (DE) Krankenhaus Hietzing mit Neurologischem Zentrum Rosenhügel AT Austria (AT)

How to cite

APA:

Kolios, A.G.A., Hueber, A., Michetti, P., Mrowietz, U., Mustak-Blagusz, M., Sator, P.-G.,... Schiefke, I. (2019). ALIGNed on adherence: subanalysis of adherence in immune-mediated inflammatory diseases in the DACH region of the global ALIGN study. Journal of the European Academy of Dermatology and Venereology, 33(1), 234-241. https://dx.doi.org/10.1111/jdv.15179

MLA:

Kolios, A. G. A., et al. "ALIGNed on adherence: subanalysis of adherence in immune-mediated inflammatory diseases in the DACH region of the global ALIGN study." Journal of the European Academy of Dermatology and Venereology 33.1 (2019): 234-241.

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