Erlangen Score Predicts Cognitive and Neuroimaging Progression in Mild Cognitive Impairment Stage of Alzheimer's Disease
Skillbäck T, Kornhuber J, Blennow K, Zetterberg H, Lewczuk P (2019)
Publication Type: Journal article
Publication year: 2019
Journal
Book Volume: 69
Pages Range: 551-559
Journal Issue: 2
DOI: 10.3233/JAD-190067
Abstract
Background: To alleviate the interpretation of the core Alzheimer's disease (AD) cerebrospinal fluid (CSF) biomarkers, amyloid β 1-42 (Aβ 42), total tau (T-tau), and phosphorylated tau (P-tau), the Erlangen Score (ES) interpretation algorithm has been proposed. Objective: In this study, we aim to assess the predictive properties of the ES algorithm on cognitive and neuroimaging outcomes in mild cognitive impairment (MCI). Methods: All MCI subjects with an available baseline CSF sample from ADNI-1 were included (n=193), and assigned an ES between 0 and 4 based on their baseline CSF biomarker profile. Structural magnetic resonance imaging brain scans and MMSE and ADAS-Cog scores were collected at up to 7 times in follow-up examinations. Results: We observed strong and significant correlations between the ES at baseline and neuroimaging and cognitive results with patients with neurochemically probable AD (ES=4) progressing significantly (p≤0.01) faster than those with a neurochemically improbable AD (ES=0 or 1), and the subjects with neurochemically possible AD (ES=2 or 3) in-between these two groups. Conclusion: This study further demonstrates the utility of the ES algorithm as a as a tool in predicting cognitive and imaging progression in MCI patients.
Authors with CRIS profile
Johannes Kornhuber
Lehrstuhl für Psychiatrie und Psychotherapie
Piotr Lewczuk
Department of Psychiatry and Psychotherapy
Involved external institutions
Sweden (SE)How to cite
APA:
Skillbäck, T., Kornhuber, J., Blennow, K., Zetterberg, H., & Lewczuk, P. (2019). Erlangen Score Predicts Cognitive and Neuroimaging Progression in Mild Cognitive Impairment Stage of Alzheimer's Disease. Journal of Alzheimer's Disease, 69(2), 551-559. https://dx.doi.org/10.3233/JAD-190067
MLA:
Skillbäck, Tobias, et al. "Erlangen Score Predicts Cognitive and Neuroimaging Progression in Mild Cognitive Impairment Stage of Alzheimer's Disease." Journal of Alzheimer's Disease 69.2 (2019): 551-559.
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