Factors affecting accuracy of S values and determination of time-integrated activity in clinical Lu-177 dosimetry

Journal article


Publication Details

Author(s): Götz TI, Schmidkonz C, Lang EW, Maier A, Kuwert T, Ritt P
Journal: Annals of Nuclear Medicine
Publication year: 2019
ISSN: 0914-7187


Abstract

Introduction: In any radiotherapy, the absorbed dose needs to be estimated based on two factors, the time-integrated activity of the administered radiopharmaceutical and the patient-specific dose kernel. In this study, we consider the uncertainty with which such absorbed dose estimation can be achieved in a clinical environment. Methods: To calculate the total error of dose estimation we considered the following aspects: The error resulting from computing the time-integrated activity, the difference between the S-value and the patient specific full Monte Carlo simulation, the error from segmenting the volume-of-interest (kidney) and the intrinsic error of the activimeter. Results: The total relative error in dose estimation can amount to 25.0% and is composed of the error of the time-integrated activity 17.1%, the error of the S-value 16.7%, the segmentation error 5.4% and the activimeter accuracy 5.0%. Conclusion: Errors from estimating the time-integrated activity and approximations applied to dose kernel computations contribute about equally and represent the dominant contributions far exceeding the contributions from VOI segmentation and activimeter accuracy.


FAU Authors / FAU Editors

Kuwert, Torsten Prof. Dr.
Lehrstuhl für Klinische Nuklearmedizin
Maier, Andreas Prof. Dr.-Ing.
Lehrstuhl für Informatik 5 (Mustererkennung)
Ritt, Philipp Dr.-Ing.
Nuklearmedizinische Klinik
Schmidkonz, Christian Dr.
Medizinische Fakultät


External institutions with authors

Universität Regensburg


How to cite

APA:
Götz, T.I., Schmidkonz, C., Lang, E.W., Maier, A., Kuwert, T., & Ritt, P. (2019). Factors affecting accuracy of S values and determination of time-integrated activity in clinical Lu-177 dosimetry. Annals of Nuclear Medicine. https://dx.doi.org/10.1007/s12149-019-01365-6

MLA:
Götz, Th I., et al. "Factors affecting accuracy of S values and determination of time-integrated activity in clinical Lu-177 dosimetry." Annals of Nuclear Medicine (2019).

BibTeX: 

Last updated on 2019-21-06 at 09:38