Factors affecting accuracy of S values and determination of time-integrated activity in clinical Lu-177 dosimetry

Götz TI, Schmidkonz C, Lang EW, Maier A, Kuwert T, Ritt P (2019)

Publication Type: Journal article

Publication year: 2019

Journal

Annals of Nuclear Medicine Springer Verlag (Germany)

DOI: 10.1007/s12149-019-01365-6

Abstract

Introduction: In any radiotherapy, the absorbed dose needs to be estimated based on two factors, the time-integrated activity of the administered radiopharmaceutical and the patient-specific dose kernel. In this study, we consider the uncertainty with which such absorbed dose estimation can be achieved in a clinical environment. Methods: To calculate the total error of dose estimation we considered the following aspects: The error resulting from computing the time-integrated activity, the difference between the S-value and the patient specific full Monte Carlo simulation, the error from segmenting the volume-of-interest (kidney) and the intrinsic error of the activimeter. Results: The total relative error in dose estimation can amount to 25.0% and is composed of the error of the time-integrated activity 17.1%, the error of the S-value 16.7%, the segmentation error 5.4% and the activimeter accuracy 5.0%. Conclusion: Errors from estimating the time-integrated activity and approximations applied to dose kernel computations contribute about equally and represent the dominant contributions far exceeding the contributions from VOI segmentation and activimeter accuracy.

Authors with CRIS profile

Christian Schmidkonz Medizinische Fakultät Andreas Maier Lehrstuhl für Informatik 5 (Mustererkennung) Torsten Kuwert Lehrstuhl für Klinische Nuklearmedizin Philipp Ritt Department of Nuclear Medicine

Involved external institutions

Universität Regensburg DE Germany (DE)

How to cite

APA:

Götz, T.I., Schmidkonz, C., Lang, E.W., Maier, A., Kuwert, T., & Ritt, P. (2019). Factors affecting accuracy of S values and determination of time-integrated activity in clinical Lu-177 dosimetry. Annals of Nuclear Medicine. https://dx.doi.org/10.1007/s12149-019-01365-6

MLA:

Götz, Th I., et al. "Factors affecting accuracy of S values and determination of time-integrated activity in clinical Lu-177 dosimetry." Annals of Nuclear Medicine (2019).

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