Renal Denervation Update From the International Sympathetic Nervous System Summit: JACC State-of-the-Art Review

Kiuchi MG, Esler MD, Fink GD, Osborn JW, Banek CT, Böhm M, Denton KM, DiBona GF, Everett TH, Grassi G, Katholi RE, Knuepfer MM, Kopp UC, Lefer DJ, Lohmeier TE, May CN, Mahfoud F, Paton JF, Schmieder R, Pellegrino PR, Sharabi Y, Schlaich MP (2019)

Publication Type: Journal article, Review article

Publication year: 2019

Journal

Book Volume: 73

Pages Range: 3006-3017

Journal Issue: 23

DOI: 10.1016/j.jacc.2019.04.015

Abstract

Three recent renal denervation studies in both drug-naïve and drug-treated hypertensive patients demonstrated a significant reduction of ambulatory blood pressure compared with respective sham control groups. Improved trial design, selection of relevant patient cohorts, and optimized interventional procedures have likely contributed to these positive findings. However, substantial variability in the blood pressure response to renal denervation can still be observed and remains a challenging and important problem. The International Sympathetic Nervous System Summit was convened to bring together experts in both experimental and clinical medicine to discuss the current evidence base, novel developments in our understanding of neural interplay, procedural aspects, monitoring of technical success, and others. Identification of relevant trends in the field and initiation of tailored and combined experimental and clinical research efforts will help to address remaining questions and provide much-needed evidence to guide clinical use of renal denervation for hypertension treatment and other potential indications.

Authors with CRIS profile

Involved external institutions

Universitätsklinikum des Saarlandes (UKS) Germany (DE) University of Minnesota (UMN) United States (USA) (US) Monash University Australia (AU) University of Iowa United States (USA) (US) Indiana University – Purdue University Indianapolis United States (USA) (US) University of Milano-Bicocca / Università degli Studi di Milano-Bicocca, UNIMIB Italy (IT) St. John's Hospital United States (USA) (US) Saint Louis University (SLU) United States (USA) (US) Louisiana State University Health Sciences Center United States (USA) (US) University of Mississippi (Ole Miss) United States (USA) (US) The University of Melbourne Australia (AU) University of Auckland New Zealand (NZ) University of Nebraska Medical Center (UNMC) United States (USA) (US) Tel Aviv University Israel (IL) University of Western Australia (UWA) Australia (AU) Baker Idi Heart And Diabetes Institute Australia (AU) Michigan State University United States (USA) (US)

How to cite

APA:

Kiuchi, M.G., Esler, M.D., Fink, G.D., Osborn, J.W., Banek, C.T., Böhm, M.,... Schlaich, M.P. (2019). Renal Denervation Update From the International Sympathetic Nervous System Summit: JACC State-of-the-Art Review. Journal of the American College of Cardiology, 73(23), 3006-3017. https://dx.doi.org/10.1016/j.jacc.2019.04.015

MLA:

Kiuchi, Márcio G., et al. "Renal Denervation Update From the International Sympathetic Nervous System Summit: JACC State-of-the-Art Review." Journal of the American College of Cardiology 73.23 (2019): 3006-3017.

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