Joint association of mammographic density adjusted for age and body mass index and polygenic risk score with breast cancer risk

Journal article


Publication Details

Author(s): Vachon CM, Scott CG, Tamimi RM, Thompson DJ, Fasching P, Stone J, Southey MC, Winham S, Lindstrom S, Lilyquist J, Giles GG, Milne RL, Macinnis RJ, Baglietto L, Li J, Czene K, Bolla MK, Wang Q, Dennis J, Häberle L, Eriksson M, Kraft P, Luben R, Wareham N, Olson JE, Norman A, Polley EC, Maskarinec G, Le Marchand L, Haiman CA, Hopper JL, Couch FJ, Easton DF, Hall P, Chatterjee N, Garcia-Closas M
Journal: Breast Cancer Research
Publication year: 2019
Volume: 21
ISSN: 1465-542X


Abstract

Background: Mammographic breast density, adjusted for age and body mass index, and a polygenic risk score (PRS), comprised of common genetic variation, are both strong risk factors for breast cancer and increase discrimination of risk models. Understanding their joint contribution will be important to more accurately predict risk.


FAU Authors / FAU Editors

Fasching, Peter PD Dr.
Professur für Translationale Frauenheilkunde und Geburtshilfe


External institutions with authors

Cancer Council Victoria
Curtin University
Genome Institute of Singapore
Harvard University
Karolinska Institute
Mayo Clinic
Monash University
National Cancer Institute (NCI)
The University of Melbourne
University of Cambridge
University of Hawaii (U.H.)
University of Southern California (USC)
University of Washington


How to cite

APA:
Vachon, C.M., Scott, C.G., Tamimi, R.M., Thompson, D.J., Fasching, P., Stone, J.,... Garcia-Closas, M. (2019). Joint association of mammographic density adjusted for age and body mass index and polygenic risk score with breast cancer risk. Breast Cancer Research, 21. https://dx.doi.org/10.1186/s13058-019-1138-8

MLA:
Vachon, Celine M., et al. "Joint association of mammographic density adjusted for age and body mass index and polygenic risk score with breast cancer risk." Breast Cancer Research 21 (2019).

BibTeX: 

Last updated on 2019-07-06 at 11:08