Vegetable hierarchical structures as template for bone regeneration: New bio-ceramization process for the development of a bone scaffold applied to an experimental sheep model
Filardo G, Roffi A, Fey T, Fini M, Giavaresi G, Marcacci M, Martínez-Fernández J, Martini L, Ramírez-Rico J, Salamanna F, Sandri M, Sprio S, Tampieri A, Kon E (2019)
Publication Type: Journal article
Publication year: 2019
Journal
DOI: 10.1002/jbm.b.34414
Abstract
Long bone defects still represent a major clinical challenge in orthopedics, with the inherent loss of function considerably impairing the quality of life of the affected patients. Thus, the purpose of this study was to assess the safety and potential of bone regeneration offered by a load-bearing scaffold characterized by unique hierarchical architecture and high strength, with active surface facilitating new bone penetration and osseointegration in critical size bone defects. The results of this study showed the potential of bio-ceramization processes applied to vegetable hierarchical structures for the production of new wood-derived bone scaffolds, further improved by surface functionalization, with good biological and mechanical properties leading to successful treatment of critical size bone defects in the sheep model. Future studies are needed to evaluate if these scaffolds prototypes, as either biomaterial alone or in combination with augmentation strategies, may represent an optimal solution to enhance bone regeneration in humans.
Authors with CRIS profile
Involved external institutions
Rizzoli Orthopaedic Institute / Istituto Ortopedico Rizzoli (IRCCS)
Italy (IT)
Institute of science and technology for ceramics (ISTEC)
Italy (IT)
University of Seville / Universidad de Sevilla
Spain (ES)
Humanitas University
Italy (IT)
Italy (IT)
Institute of science and technology for ceramics (ISTEC)
Italy (IT)
University of Seville / Universidad de Sevilla
Spain (ES)
Humanitas University
Italy (IT)
How to cite
APA:
Filardo, G., Roffi, A., Fey, T., Fini, M., Giavaresi, G., Marcacci, M.,... Kon, E. (2019). Vegetable hierarchical structures as template for bone regeneration: New bio-ceramization process for the development of a bone scaffold applied to an experimental sheep model. Journal of Biomedical Materials Research Part B: Applied Biomaterials. https://dx.doi.org/10.1002/jbm.b.34414
MLA:
Filardo, Giuseppe, et al. "Vegetable hierarchical structures as template for bone regeneration: New bio-ceramization process for the development of a bone scaffold applied to an experimental sheep model." Journal of Biomedical Materials Research Part B: Applied Biomaterials (2019).
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