Update Breast Cancer 2019 Part 3 - Current Developments in Early Breast Cancer: Review and Critical Assessment by an International Expert Panel

Kolberg HC, Schneeweiss A, Fehm TN, Wöckel A, Huober J, Pontones C, Titzmann A, Belleville E, Lux MP, Janni W, Hartkopf AD, Taran FA, Wallwiener M, Overkamp F, Tesch H, Ettl J, Lüftner D, Müller V, Schütz F, Fasching P, Brucker SY (2019)

Publication Type: Journal article

Publication year: 2019

Journal

Geburtshilfe und Frauenheilkunde Georg Thieme Verlag

Book Volume: 79

Pages Range: 470-482

Journal Issue: 5

DOI: 10.1055/a-0887-0861

Abstract

The treatment of breast cancer patients in a curative situation is special in many ways. The local therapy with surgery and radiation therapy is a central aspect of the treatment. The complete elimination of tumour cells at the site of the primary disease must be ensured while simultaneously striving to keep the long-term effects as minor as possible. There is still focus on the continued reduction of the invasiveness of local therapy. With regard to systemic therapy, chemotherapies with taxanes, anthracyclines and, in some cases, platinum-based chemotherapies have become established in the past couple of decades. The context for use is being continually further defined. Likewise, there are questions in the case of antihormonal therapy which also still need to be further defined following the introduction of aromatase inhibitors, such as the length of therapy or ovarian suppression in premenopausal patients. Finally, personalisation of the treatment of early breast cancer patients is also being increasingly used. Prognostic tests could potentially support therapeutic decisions. It must also be considered how the possible use of new therapies, such as checkpoint inhibitors and CDK4/6 inhibitors could look in practice once study results in this regard are available. This overview addresses the backgrounds on the current votes taken by the international St. Gallen panel of experts in Vienna in 2019 for current questions in the treatment of breast cancer patients in a curative situation.

Authors with CRIS profile

Constanza Pontones Department of Obstetrics and Gynaecology Adriana Titzmann Department of Obstetrics and Gynaecology Peter Fasching Professur für Translationale Frauenheilkunde und Geburtshilfe

Involved external institutions

Marienhospital Bottrop DE Germany (DE) Deutsches Krebsforschungszentrum (DKFZ) DE Germany (DE) Universitätsklinikum Würzburg DE Germany (DE) Universitätsklinikum Düsseldorf DE Germany (DE) Universitätsklinikum Ulm DE Germany (DE) ClinSol GmbH & Co.KG DE Germany (DE) OncoConsult DE Germany (DE) Eberhard Karls Universität Tübingen DE Germany (DE) Ruprecht-Karls-Universität Heidelberg DE Germany (DE) Klinikum rechts der Isar DE Germany (DE) Agaplesion Markus Krankenhaus DE Germany (DE) Charité - Universitätsmedizin Berlin DE Germany (DE) Kooperatives Brustzentrum Paderborn DE Germany (DE) Universitätsklinikum Hamburg-Eppendorf (UKE) DE Germany (DE)

How to cite

APA:

Kolberg, H.C., Schneeweiss, A., Fehm, T.N., Wöckel, A., Huober, J., Pontones, C.,... Brucker, S.Y. (2019). Update Breast Cancer 2019 Part 3 - Current Developments in Early Breast Cancer: Review and Critical Assessment by an International Expert Panel. Geburtshilfe und Frauenheilkunde, 79(5), 470-482. https://doi.org/10.1055/a-0887-0861

MLA:

Kolberg, Hans Christian, et al. "Update Breast Cancer 2019 Part 3 - Current Developments in Early Breast Cancer: Review and Critical Assessment by an International Expert Panel." Geburtshilfe und Frauenheilkunde 79.5 (2019): 470-482.

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