Threshold Isocontouring on High b-Value Diffusion-Weighted Images in Magnetic Resonance Mammography
Zong F, Bickelhaupt S, Kuder TA, Lederer W, Daniel H, Stieber A, Schlemmer HP, Galvosas P, Laun FB (2019)
Publication Type: Journal article
Publication year: 2019
Journal
Book Volume: 43
Pages Range: 434-442
Journal Issue: 3
DOI: 10.1097/RCT.0000000000000868
Abstract
OBJECTIVES: Motivated by the similar appearance of malignant breast lesions in high b-value diffusion-weighted imaging (DWI) and positron emission tomography, the purpose of this work was to evaluate the applicability of a threshold isocontouring approach commonly used in positron emission tomography to analyze DWI data acquired from female human breasts with minimal interobserver variability. METHODS: Twenty-three female participants (59.4 ± 10.0 years) with 23 lesions initially classified as suggestive of cancers in x-ray mammography screening were subsequently imaged on a 1.5-T magnetic resonance imaging scanner. Diffusion-weighted imaging was performed prior to biopsy with b values of 0, 100, 750, and 1500 s/mm. Isocontouring with different threshold levels was performed on the highest b-value image to determine the voxels used for subsequent evaluation of diffusion metrics. The coefficient of variation was computed by specifying 4 different regions of interest drawn around the lesion. Additionally, a receiver operating statistical analysis was performed. RESULTS: Using a relative threshold level greater than or equal to 0.85 almost completely suppresses the intra-individual and inter-individual variability. Among 4 studied diffusion metrics, the diffusion coefficients from the intravoxel incoherent motion model returned the highest area under curve value of 0.9. The optimal cut-off diffusivity was found to be 0.85 μm/ms with a sensitivity of 87.5% and specificity of 90.9%. CONCLUSION: Threshold isocontouring on high b-value maps is a viable approach to reliably evaluate DWI data of suspicious focal lesions in magnetic resonance mammography.
Authors with CRIS profile
Involved external institutions
Victoria University of Wellington
New Zealand (NZ)
Universitätsklinikum Heidelberg
Germany (DE)
RadiologieZentrumMannheim
Germany (DE)
ATOS-Praxisklinik Heidelberg
Germany (DE)
Deutsches Krebsforschungszentrum (DKFZ)
Germany (DE)
New Zealand (NZ)
Universitätsklinikum Heidelberg
Germany (DE)
RadiologieZentrumMannheim
Germany (DE)
ATOS-Praxisklinik Heidelberg
Germany (DE)
Deutsches Krebsforschungszentrum (DKFZ)
Germany (DE)
How to cite
APA:
Zong, F., Bickelhaupt, S., Kuder, T.A., Lederer, W., Daniel, H., Stieber, A.,... Laun, F.B. (2019). Threshold Isocontouring on High b-Value Diffusion-Weighted Images in Magnetic Resonance Mammography. Journal of Computer Assisted Tomography, 43(3), 434-442. https://doi.org/10.1097/RCT.0000000000000868
MLA:
Zong, Fangrong, et al. "Threshold Isocontouring on High b-Value Diffusion-Weighted Images in Magnetic Resonance Mammography." Journal of Computer Assisted Tomography 43.3 (2019): 434-442.
BibTeX: Download