2017 WONOEP appraisal: Studying epilepsy as a network disease using systems biology approaches
Mahoney JM, Mills JD, Muhlebner A, Noebels J, Potschka H, Simonato M, Kobow K (2019)
Publication Type: Journal article, Review article
Publication year: 2019
Journal
Book Volume: 60
Pages Range: 1045-1053
Journal Issue: 6
DOI: 10.1111/epi.15216
Abstract
The revolution in high-throughput omics technologies has dramatically expanded our understanding of the epilepsies as complex diseases. It is now clear that further progress in treating the full spectrum of seizure disorders requires a systems-level framework for analyzing and integrating data from multiple omics technologies that moves beyond the search for single molecular alterations to an understanding of dysregulated pathways in epilepsy. Taking such a pathway-centered view requires further integrating the tools of systems biology into epilepsy research. In this appraisal, we highlight and summarize systems biology approaches in basic epilepsy studies as they were discussed during the 2017 Workshop on the Neurobiology of Epilepsy (WONOEP). During the 3-day event, participants exchanged emerging results and thoughts on developing the systems biology of epilepsy, and the promise and limitations of these approaches for the near term.
Authors with CRIS profile
Involved external institutions
Academic Medical Centre / Academisch Medisch Centrum (AMC)
Netherlands (NL)
Baylor College of Medicine
United States (USA) (US)
University of Vermont
United States (USA) (US)
Università degli Studi di Ferrara
Italy (IT)
Ludwig-Maximilians-Universität (LMU)
Germany (DE)
Netherlands (NL)
Baylor College of Medicine
United States (USA) (US)
University of Vermont
United States (USA) (US)
Università degli Studi di Ferrara
Italy (IT)
Ludwig-Maximilians-Universität (LMU)
Germany (DE)
How to cite
APA:
Mahoney, J.M., Mills, J.D., Muhlebner, A., Noebels, J., Potschka, H., Simonato, M., & Kobow, K. (2019). 2017 WONOEP appraisal: Studying epilepsy as a network disease using systems biology approaches. Epilepsia, 60(6), 1045-1053. https://dx.doi.org/10.1111/epi.15216
MLA:
Mahoney, John M., et al. "2017 WONOEP appraisal: Studying epilepsy as a network disease using systems biology approaches." Epilepsia 60.6 (2019): 1045-1053.
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