2017 WONOEP appraisal: Studying epilepsy as a network disease using systems biology approaches

Beitrag in einer Fachzeitschrift
(Review-Artikel)


Details zur Publikation

Autorinnen und Autoren: Mahoney JM, Mills JD, Muhlebner A, Noebels J, Potschka H, Simonato M, Kobow K
Zeitschrift: Epilepsia
Jahr der Veröffentlichung: 2019
ISSN: 0013-9580


Abstract

The revolution in high-throughput omics technologies has dramatically expanded our understanding of the epilepsies as complex diseases. It is now clear that further progress in treating the full spectrum of seizure disorders requires a systems-level framework for analyzing and integrating data from multiple omics technologies that moves beyond the search for single molecular alterations to an understanding of dysregulated pathways in epilepsy. Taking such a pathway-centered view requires further integrating the tools of systems biology into epilepsy research. In this appraisal, we highlight and summarize systems biology approaches in basic epilepsy studies as they were discussed during the 2017 Workshop on the Neurobiology of Epilepsy (WONOEP). During the 3-day event, participants exchanged emerging results and thoughts on developing the systems biology of epilepsy, and the promise and limitations of these approaches for the near term.


Einrichtungen weiterer Autorinnen und Autoren

Academic Medical Centre / Academisch Medisch Centrum (AMC)
Baylor College of Medicine
Ludwig-Maximilians-Universität (LMU)
Università degli Studi di Ferrara
University of Vermont


Zitierweisen

APA:
Mahoney, J.M., Mills, J.D., Muhlebner, A., Noebels, J., Potschka, H., Simonato, M., & Kobow, K. (2019). 2017 WONOEP appraisal: Studying epilepsy as a network disease using systems biology approaches. Epilepsia. https://dx.doi.org/10.1111/epi.15216

MLA:
Mahoney, John M., et al. "2017 WONOEP appraisal: Studying epilepsy as a network disease using systems biology approaches." Epilepsia (2019).

BibTeX: 

Zuletzt aktualisiert 2019-29-05 um 13:38